伐地那非、十一酸睾酮合用与单用伐地那非治疗糖尿病患者勃起功能障碍的疗效比较

目的比较联合应用伐地那非和十一酸睾酮与单用伐地那非治疗糖尿病患者勃起功能障碍的疗效及不良反应。方法该院男科门诊患有糖尿病的勃起功能障碍患者58例,随机分成A、B组,每组29例,A组口服伐地那非20mg,性生活前30min服用;B组除了同样服用伐地那非外,每日早晚饭后服用十一酸睾酮40mg,共观察12周。比较两组治疗前后的国际勃起功能指数-5(IIEF-5)问卷中的评分、每周性交频率以及治疗期间的不良反应,并评估在疗程结束时,患者及其配偶对性生活的满意程度。结果 A、B两组患者IIEF-5评分在治疗后均显著增加,而B组较A组增加更显著(P<0.05);治疗后每周性交频率两组均显著增多,两组之间比较B组增加更明显(P<0.05)。治疗结束时,A组患者对性生活感到满意的有15例(51.7%),B组有21例(72.4%),B组满意比例较A组更高(P<0.05)。在不良反应方面,B组患者共有6例(20.7%)发生不良反应,较A组的5例(17.2%)无统计学意义(P>0.05)。结论在对糖尿病患者勃起功能障碍的治疗上,联合应用伐地那非和十一酸睾酮比单用伐地那非治疗糖尿病患者勃起功能障碍疗效要好,同时引起的不良反应却无明显增加。

Comparison between vardenafil plus testosterone undecanoate and vardena-fil alone in the treatment of diabetic patients with erectile dysfunction

Aim To compare the efficacy and safety of vardenafil plus testosterone undecanoate with those of vardenafil alone in the treatment of diabetic patients with erectile dysfunction（ED）.Methods Fifty-eight patients with diabetic ED were enrolled in this study.They were randomly divided into Groups A and B of equal number.Group A received 20 mg vardenafil 30min before planned sexual activity for 12 weeks,and Group B were given 20 mg vardenafil 30min before sexual activity plus 40 mg testosterone undecanoate after breakfast and supper daily for 12 weeks.Before and after the treatment,IIEF-5 score,the intercourse satisfaction,the mean number of coituses per week and the drug-related side effects were evaluated.Results IIEF-5 scores were（11.3±0.9）,（17.5±1.7）respectively at baseline and post-treatment in Group A,and（10.9±1.2）,（22.3±2.5）（P0.01）in Group B,improved in both of the two groups,but more significantly in Group B（P〈0.05）.The mean numbers of coituses per week in Groups A and B were（0.8±0.3）,（1.7±0.8）（P〈0.01）and（0.9±0.5）,（2.5±0.9）（P〈0.01）respectively,significantly larger in Group B（P〈0.05）after the treatment.As for the side effects,there was no significant difference（P〉0.05）in Group B and in Group A.Conclusions Testosterone undecanoate combined with vardenafil can produce significantly better results than vardenafil alone in diabetic patients with erectile dysfunction.In the meantime,the combined treatment is associated with no increase in the drug-related side effects.