盐酸氨溴索和肺表面活性物质在防治新生儿呼吸窘迫综合征中的疗效分析

目的：比较盐酸氨溴索和肺表面活性物质（PS）防治新生儿呼吸窘迫综合征（NRDS）的效果。方法：2006年1月～2009年6月我院早产儿100例随机分为三组，均给予相同的常规治疗。A组只给予常规治疗；B组加用盐酸氨溴索；C组气管插管滴入PS。比较三组NRDS发生率、需呼吸机治疗比例、常见并发症发生率及死亡率。结果：B组、C组与A组比较，各项指标均有显著性差异；B组与C组比较，C组疗效高，但无显著性差异。结论：盐酸氨溴索和PS均能有效防治NRDS的发生、发展，二者疗效相当。

Effect analysis of Ambroxol Hydrochloride and pulmonary surfactant in prevention and treatment of neonatal respiratory distress syndrome

Objective： To compare the effect of Ambroxol Hydrochloride and pulmonary surfactant （PS） in prevention and treatment of neonatal respiratory distress syndrome （NRDS）. Methods： From January 2006 to June 2009 in our Hospital, 100 cases of neonatal premature children were randomly divided into 3 groups and they were given the same routine treatment. Group A was only given routine treatment, group B was given Ambroxol Hydrochloride, group C instilled PS through tracheal intubation. The incidence of NRDS, the proportion required ventilation therapy, the incidence of complications and mortality of the 3 groups were compared. Results： Group B and group C compared with group A, the index had significant difference; group B compared with group C, group C had higher efficacy than group B, but the difference was not statistically significant. Conclusion： Ambroxol Hydrochloride and PS can effectively prevent the occurrence and development of NRDS, and both very effective.