睡眠呼吸暂停综合征及鼾症患者事件相关电位的研究

目的　研究睡眠呼吸暂停及鼾症患者事件相关电位 (P3)的情况 ,探讨可能的机制。方法　入组受试者分为睡眠呼吸暂停患者组 2 1例、鼾症组 2 1例及正常对照组 2 1例 ,均进行睡眠多导仪、听觉诱发事件相关电位 (P3)、临床记忆量表检查及神经系统查体。结果采用GLM程序分析。结果　睡眠呼吸暂停患者组记忆商 (MQ) 90± 12 ,P3潜伏期Fz记录点 :36 3ms± 2 3ms ,Cz记录点 :36 9ms± 2 8ms;鼾症组MQ :10 1± 17,P3潜伏期 :Fz记录点 :337ms± 31ms ,Cz记录点 :340ms± 32ms ;正常对照组MQ :114± 12 ,P3潜伏期 :Fz记录点 :341ms± 2 9ms ,Cz记录点 338ms± 30ms。睡眠呼吸暂停患者组与鼾症组、正常对照组的P3潜伏期和记忆商比较差异有显著意义 (P <0 0 5 )。鼾症患者记忆商较正常对照组降低。结论　睡眠呼吸暂停患者有认知功能损害。鼾症患者记忆功能减退。夜间低氧血症可能起重要作用

Abnormal P3 latency in obstructive sleep apnea syndrome, but normal in snore

OBJECTIVE: To evaluate the P3 wave (latency, amplitude) in snorers and patients with obstructive sleep apnea syndrome (OSAS) and investigate the possible mechanism. METHODS: Three groups, OSAS patient group (n = 21), snorer group (n = 21) and control group (n = 21), were administered polysomnography (PSG), auditory evoked event-related potential (P3) and clinic memory test. The results were analyzed using GLM analysis and Post Hoc test. RESULTS: The auditory P3 latency in OSAS group was 363 ms +/- 22 ms (Fz), 369 ms +/- 28 ms (Cz), in snorer group 336 ms +/- 31 ms (Fz), 340 ms +/- 32 ms (Cz), and in control group 341 ms +/- 29 ms (Fz), 338 ms +/- 30 ms (Cz). There were significant differences between OSAS group and snorer group, as well as control group (P < 0.05). No significant difference was seen between snorer group and control group. Memory quotient (MQ) was reduced in snoren group as compared with control group. CONCLUSION: Abnormal auditory P3 latency indicates the cognitive dysfunction in OSAS patients. Nocturnal hypoxaemia may play an important role.