夫西地酸钠相关肝损害

1例41岁男性患者因延迟关胸术后肺部感染使用夫西地酸钠0.5g,1次/8h静脉滴注。用药第3天,患者出现皮肤及巩膜黄染,B超示肝脏体积增大,实验室检查：ALT68U/L,AST43U/L,ALP58U/L,γ-GT42U/L,TBil121.8μmol/L,DBil73.3μmol/L。停用夫西地酸钠,改用万古霉素,并进行对症治疗。3周后肝功能恢复正常。

Liver damage associated with sodium fusidate

A 41-year-old man received an IV infusion of sodium fusidate 0.5 g every eight hours for pulmonary infection after undergoing an operation of delayed sternal closure. On day3 after drug administration,the patient developed yellowish skin and sclera.B-ultrasound showed an increase in liver volume. Laboratory tests revealed the following levels：ALT 68 U/L,AST 43 U/L,ALP58 U/L,γ-GT42 U/L,TBil 121.8μmol/L,and DBil 73.3μmol/L. Sodium fusidate was stopped and switched to vancomycin.Meanwhile he was given symptomatic therapy. Three weeks later,his liver function returned to within normal range.