胃癌术后腹腔化疗和静脉化疗的疗效比较

目的　比较进展期胃癌术后腹腔化疗和静脉化疗的临床疗效。方法　将 68例进展期胃癌术后化疗按前瞻、随机、对照的原则分为治疗组 (腹腔化疗 ) 3 3例及对照组 (静脉化疗 ) 3 5例 ,比较两组治疗的不良反应发生率、腹腔内复发率、肝转移率、3年生存率的差异。结果　治疗组胃肠反应率、骨髓抑制率、腹腔内复发率、肝转移率、3年无瘤生存率、3年生存率分别为 12 .1%、9.0 %、18.1%、12 .1%、2 3 .6%、5 4.5 %。对照组胃肠反应率、骨髓抑制率、腹腔内复发率、肝转移率、3年无瘤生存率、3年生存率分别为 91.3 %、85 .7%、60 .0 %、3 7.1%、12 .8%、3 4.3 %。结论　与静脉化疗比较 ,进展期胃癌术后腹腔化疗的不良反应发生率、腹腔内复发率、肝转移率、3年生存率率降低 ,差异有显著性 (P <0 .0 5 )。

Comparison of the effectiveness of postoperative intravenous chemotherapy and intraperitoneal chemotherapy for advanced gastric cancer

Objective To compare the clinical effectiveness of postoperative intravenous chemotherapy and intraperitoneal chemotherapy for advanced gastric cancer.Methods Sixty-eight postoperative patients with advanced gastric carcinoma were divided into two groups:treatment group receiving intraperitoneal chemotherapy(n=33) and control group subject to intravenous chemotherapy(n=35).The incidence of side-effects,intraperitoneal recurrence rate, hepatic metastatic rate and 3-year survival rate were compared between the two groups.Results Vomit,marrow restrain and the local and hepatic recurrence,3 year disease-free survival rate and 3 year overall survival rate in the treatment group were 12.1%,9.0%,18.1%,12.1%,23.6% and 54.5% respectively,while those in the control group were 91.3%,85.7%,60.0%,37.1%,12.8% and 34.3%,respectively (all P<0.05).Conclusion Intraperitoneal chemotherapy is an effective way to prevent side-effect and the local and hepatic recurrence after advanced gastric carcinoma operation.