The effect of 2,5-hexanedione on myelin protein zero expression, and its mitigation using Ginkgo biloba extract |
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| Authors: | Zhao Lei Liu QingJun Chen Hong Duan HuaWei Bin Ping Liu Qing Niu Yong Dai YuFei Zheng YuXin |
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| Institution: | ZHAO Lei,LIU QingJun,CHEN Hong,DUAN HuaWei,BIN Ping,LIU Qing,NIU Yong,DAI YuFei,and ZHENG YuXin National Institute for Occupational Health and Poison Control and Key laboratory of Chemical Safety and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China |
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| Abstract: | Objective To investigate the role of myelin protein zero (P 0) in 2,5-hexanedione (2,5-HD)-induced peripheral nerve injury,and the protective effect of Ginkgo biloba extract (Egb761) on 2,5-HD-induced toxic peripheral neuropathy.Methods After 4 weeks of treatment with 2,5-HD at different doses (50,100,200,400 mg/kg) in rats,changes in the levels of P 0 in rat sciatic nerves was investigated,and the effect of Egb761 on 2,5-HD-induced toxic peripheral neuropathy was studied.Results The blood-nerve barrier (BN... |
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| Keywords: | Myelin protein zero 2 5-hexanedione Ginkgo biloba extract |
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