An assessment of androgenic/anti-androgenic effects of GH transgenic carp by Hershberger assay |
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| Authors: | Liu YuMei Zhang WenZhong Yong Ling Zhao XiaoHong Jia XuDong Li Ning |
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| Institution: | LIU YuMei 1,2,ZHANG WenZhong 2,YONG Ling 2,ZHAO XiaoHong 1,JIA XuDong 2,and LI Ning 2,1.College of Applied Arts and Sciences,Beijing Union University,Beijing 100191,China 2.National Institute for Nutrition and Food Safety,China CDC,Beijing 100021,China |
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| Abstract: | Objective To evaluate the androgenic and anti-androgenic effects of GH (growth hormone) transgenic carp in male rats.Methods Hershberger assay was carried out in castrated male SD rats aged 4-5 weeks.Testosterone propionate (TP) (0.4 mg/kg BW) was administrated for a positive control,GH transgenic carp (3.0 g/kg BW)+TP (0.4 mg/kg BW),parental carp (3.0 g/kg BW) + TP (0.4 mg/kg BW),and flutamide (Flu) (3.0 g/kg BW) were used for negative controls,and vehicle was administered orally for a blank control.All gr... |
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| Keywords: | GH gene transgenic carp Hershberger assay Androgenic properties |
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