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Identification of estrogen-associated intrinsic aging genes in Chinese Han female skin by cDNA microarray technology |
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| Authors: | Yan Wei Zhao ZhenMin Zhang LiLi Wang DunMei Yan Li Yin NingBei Wu Di Zhang Feng |
| Institution: | YAN Wei 1,ZHAO ZhenMin 1,ZHANG LiLi 2,WANG DunMei 2,YAN Li 1,YIN NingBei 1,WU Di 1,and ZHANG Feng 2 1.Plastic Surgery Hospital,Chinese Academy of Medical Science,Peking Union Medical College,Beijing 100144,China 2.CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100029,China |
| Abstract: | Objective Estrogens play an important role in intrinsic skin aging.The associated changes in global gene expression are poorly understood.Methods We used the Illumina microarray platform to obtain comprehensive gene expression profiles in female Chinese Han skin,and confirmed the data by quantitative real-time PCR (Q-RT-PCR).Results We found 244 genes significantly related to estrogen-associated intrinsic skin aging,and some of these genes were confirmed by Q-RT-PCR.We also performed functional analysis by ... |
| Keywords: | Estrogen Intrinsic aging Microarray Metabolism |
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