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The effect of trimethoprim-sulphamethoxazole on sebum excretion rate and biochemistry in acne vulgaris |
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| Authors: | J A Cotterill W J Cunliffe B Williamson |
| Abstract: | SUMMARY.— The sebum excretion rate and skin surface liquid composition were determined before and after 1 and 2 months of therapy in patients taking a trimethoprim-sulphamethoxazole combination for acne vulgaris. Trimethoprim-sulphamethoxazole caused a significant reduction in skin surface free fatty acid and a significant rise in skin surface triglyceride after 1 and 2 mionths of therapy. There were no significant changes in sebum excretion rate, squalene or wax ester. |
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