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耳蜗急性纯音损伤后下丘及耳蜗核快速功能重组
引用本文:王坚,丁大连.耳蜗急性纯音损伤后下丘及耳蜗核快速功能重组[J].中华耳鼻咽喉科杂志,1997,32(4):218-221.
作者姓名:王坚  丁大连
摘    要:实验比较高强度纯音损伤耳蜗局部区域前后,耳蜗背核及下丘接近损伤区边缘的神经元反应特性的改变。致损纯音的频率高于神经元的特征频率,且位于其兴奋区以外,所以不影响其兴奋性输入,结果发现此种纯音损伤在逾半数的神经元产生不同程度的去抑制效应,提示皮歧的功能重组可能部分地起源于低位中枢的功能改变,下丘和耳蜗背核的抑制性神经网络具有相当程度的侧抑制组分。

关 键 词:耳蜗疾病  下丘  听力障碍  功能重建  耳蜗核

Rapid functional plasticity of the neurons in the inferior colliculus and dorsal cochlear nucleus after brief exposure to intense pure tone]
J Wang,D Ding.Rapid functional plasticity of the neurons in the inferior colliculus and dorsal cochlear nucleus after brief exposure to intense pure tone][J].Chinese Journal of Otorhinolaryngology,1997,32(4):218-221.
Authors:J Wang  D Ding
Institution:Richard J. Salvi. Center for Hearing & Deafness, State University of New York at Buffalo 14214, USA.
Abstract:The changes of response properties were observed from the single neuron in inferior colliculus (IC) and dorsal cochlear nucleus (DCN) located in the area bordering the lesion created by intense pure tone. The frequencies of traumatizing tone were chosen higher than the characteristic frequency (CF) of the neurons and beyond their excitatory response area so that the traumatizing tone would not influence the excitatory input to the neurons under study. Different types of disinhibition effects were found in more than half of the neurons after the traumatizing tone. The results indicated a subcortical origination of cortical functional reorganization and the involvement of lateral inhibition in the formation of inhibitory neural networks in both IC and DCN.
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