厄贝沙坦干预对糖尿病肾病大鼠IL-6和CRP水平的影响

目的探讨血管紧张素Ⅱ受体拮抗剂厄贝沙坦对糖尿病大鼠肾脏的保护作用及其相关机制。方法将36只Wistar大鼠随机分为对照组、糖尿病肾病组、厄贝沙坦治疗组3组,每组12只。第8周、12周末收集大鼠血、尿标本,测定血液C反应蛋白（CRP）、白细胞介素6（IL-6）、血糖、肌酐、尿素氮含量,测定尿液24h尿白蛋白含量。结果第8周、12周末糖尿病各组大鼠的血糖、肌酐、尿素氮、24 h尿白蛋白、CRP和IL-6水平均明显高于对照组,厄贝沙坦治疗组大鼠的血糖、肌酐、尿素氮2、4 h尿白蛋白、CRP和IL-6水平均明显低于糖尿病肾病组。结论厄贝沙坦能延缓糖尿病大鼠肾脏功能损害的进展,其机制可能与厄贝沙坦不同程度地抑制糖尿病肾病大鼠CRP和IL-6的产生有关。

Effect of irbesrtan on interleukin 6 and C reactive protein

Objective To investigate the protective effect of kidney of irbesrtan in diabetic nephropathy rats.Methods 36 Wistar rats were randomly divided into three group,including control group,diabetic nephropathy group and irbesartan group.At the weekends of the 8th and the 12th,serum and urine of the rats was collected.The levels of C reactive protein,interleukin 6,glucose,creatinine,urea nitrogen in serum and 24-hour urinaryalbumin were determined.Result The levels of C reactive protein,interleukin 6,glucose,creatinine,urea nitrogen and 24-hour urinaryalbumin in diabetic nephropathy group were significantly higher than that in control group.However,the levels of C reactive protein,interleukin 6,glucose,creatinine,urea nitrogen and 24-hour urinaryalbumin in irbesartan treatment group were significantly lower than that in diabetic nephropathy group.Conclusion Irbesartan can delay the progress of the renal function impairment of diabetic nephropathy rats.It may be associated with the mechanism that irbesartan inhibits the production of C reactive protein and interleukin 6 in blood of diabetic nephropathy rats.