Ultrastructural Morphology of Folliculo-Stellate Cells in Human Pituitary Adenomas |
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| Authors: | Andrea Sbarbati Adnan Fakhreddine Carlo Zancanaro Lamberto Bontempini Saverio Cinti |
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| Institution: |
a Institute of Anatomy and Histology, University of Verona, Italy
b Department of Neurosurgery, University of Verona, Italy
c Institute of Human Anatomy and Histology, University of Verona, Italy
d Department of Pathology, Verona City Hospital, Verona, Italy
e Institute of Normal Human Morphology, University of Ancona, Italy |
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| Abstract: | Fifty-six pituitary adenomas were studied by electron microscopy in a search for the presence of folliculo-stellate cells (FSCs) with the aim of evaluating their prevalence and ultrastructural morphology. FSCs were scattered in two adenomas (one oncocytoma and one densely granulated GH cell adenoma) and were numerous in a sparsely granulated GH cell adenoma; their overall prevalence was 5.4%. Ultrastructural examination of the three neoplasms revealed that FSCs were hypertrophic element with abundant cytoplasm and organelles (in contrast to FSCs of the normal pituitary) and no obvious signs of neoplastic transformation. Junctional complexes between FSCs were similar to those described in the normal gland. Numerous follicular structures were lined by FSCs. FSCs in pituitary adenomas are probably nonneoplastic, reactive cells showing signs of hyperactivity, similar to FSCs found during pituitary hypersecretion and in estrogen-induced tumor. |
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| Keywords: | folliculo-stellate cell hypophysis pituitary adenoma ultrastructure |
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