HBV 感染、家族肝癌史与 ABO 血型在低发区原发性肝癌的关系

本文研究了高、低发区５１０例ＰＨＣＨＢＶ感染、家族肝癌史及与ＡＢＯ血型的关系，结果表明：１肝癌低发区与高发区一样，合并ＨＢＶ感染的ＰＨＣ患者达８０．７４％，远多于无ＨＢＶ感染者；男性多于女性；有家族肝癌史的ＰＨＣ患者占４０．００％，且合并ＨＢＶ感染的ＰＨＣ有家族肝癌史者显著多于ＨＢＶ阴性组（Ｐ＜０．０５）；２低发区ＰＨＣ中，有家族肝癌史的Ａ型血者显著多于相应对照组（Ｐ＜０．０５）。提示我国肝癌低发区ＰＨＣ发生的最重要外因亦为ＨＢＶ感染，遗传易感性则是其内因；而有ＨＢＶ感染或有家族肝癌史者是ＰＨＣ的高危人群，且后者中的Ａ型血者更为易患，对这一人群需加强监测，警惕ＰＨＣ的发生。

HBV Infection,Family History and ABO BLood Group of PHC Patients in Low Risk Areas

The relation in HBV infection,family history of PHC and ABO blood group was studied by investigating 510 cases of PHC in high and Low risk areas. The results showed:(1)It was similar in various areas that PHC patients with HBV infection were far more than those with no HBV infection;and male patients were more than female. There were 40% of PHC patients having family history. The People of family history in the group of PHC with HBV infection were far more than those in the group of PHC with no HBV infection(P<0.05).(2)In low risk areas,bLood group A of PHC having family history was obviously higher than that of control (P<0.05).These suggested that in low risk areas of our country the most important extra factor of PHC was HBV infection while family history of PHC being the intra factor. People with HBV infection or family history were high risk population of PHC, and people in blood group A with family history of PHC were more susceptible to PHC. It needed to pay more attention to following up these pelple and keep Vigilant guard over PHC.