| 绞股蓝总皂甙对自由基损伤血管内皮的保护作用 |
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| 引用本文： | 肖观莲,陈剑雄,廖端芳,余麟.绞股蓝总皂甙对自由基损伤血管内皮的保护作用[J].中药药理与临床,1993(3). |
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| 作者姓名： | 肖观莲 陈剑雄 廖端芳 余麟 |
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| 作者单位： | 衡阳医学院药理教研室 421001
(肖观莲，陈剑雄，廖端芳)，衡阳医学院药理教研室 421001(余麟) |
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| 摘 要： | 本文观察了绞股蓝总皂苷(Gypenosides,GYP)对电解性自由基(OFR)损伤离体兔胸主动脉和脑基底动脉内皮的保护作用:电解性OFR使乙酰胆碱(Ach)诱导的兔主动脉环舒张百分率明显降低,舒张比值(RR)变小,使离体兔脑基底动脉灌流压升高。结果显示绞股蓝能保护血管内皮免受OFR损伤,且呈剂量依赖性,并明显抑制OFR所致灌流压升高。作用似二甲亚砜(DMSO),说明GYP对外源性OFR损伤具保护作用。
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| 关 键 词： | 绞股蓝总皂甙 氧自由基 内皮 基底动脉 |
The protective effect of Gypnosides against free radical-mediated vaccular endothelial damage |
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| Xiao Guanglian,Cheng Jianxong,Liao Duanfan,Yu Lin.The protective effect of Gypnosides against free radical-mediated vaccular endothelial damage[J].Pharmacology and Clinics of Chinese Materia Medica,1993(3). |
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| Authors: | Xiao Guanglian Cheng Jianxong Liao Duanfan Yu Lin |
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| Abstract: | The protection of Gypnosides (GYP) on vaccular endothelial damage induced by electrolytic free radicals has been observed. Electrolytic free radicals induced obvious raduction of the relaxation percentage and relaxation ratio of isolated rabbit aortia rings induced by Ach, and induced rise of perfusing pressure of isolated rabbit brain basilaris artery. Our experiment showed that GYP can protect the vaccular endothelium from damage induced by free radicals, obviously prevent the rise of perfusing pressure, and the pretective effect depended on dosage. In addition, the protection way of GYP was similar to DMSO, which suggested GYP may prevent the exoge-nic free radical-mediated damage. |
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| Keywords: | Gypnosides free radicals endothelium basilaris astery |
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