| 青蒿素对人鼻咽癌CNE细胞的放射增敏作用及机制的研究 |
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| 引用本文： | 唐艳,曹建平,樊赛军,朱巍,张旭光,陈遐林,纪蓉,潘春燕,周媛媛,封阳,江庆.青蒿素对人鼻咽癌CNE细胞的放射增敏作用及机制的研究[J].中华放射医学与防护杂志,2009,30(6):280-282. |
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| 作者姓名： | 唐艳 曹建平 樊赛军 朱巍 张旭光 陈遐林 纪蓉 潘春燕 周媛媛 封阳 江庆 |
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| 作者单位： | 南华大学公共卫生学院;苏州大学医学部放射医学与公共卫生学院江苏省放射医学与防护重点实验室,215123;徐州市肿瘤医院; |
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| 基金项目： | 国家自然科学基金教育部长江学者和创新团队发展计划 |
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| 摘 要： | Objective To investigate the radiosensitizing effects of artemisinin on CNE human nasopharyngeal carcinoma cells in vitro.Methods CNE human nasopharyngeal carcinoma cell line was used in this study.Cell growth kinetics was determined by MTT assay.Effect of the drug on radiosensitivity of CNE cells was analyzed by clonogenic assay.The change of cell cycle was measured by flow cytometry.Results The inhibition of CNE cells growth by artemisinin was increased with concentrations.Artemisinin (1 μmol/L)could enhance the radiosensitizing effects on CNE cell line,and the sensitizing enhancement ratio(SER)was 1.26.Artemisinin abrogated radiation-induced G2/M arrest of the tested CNE cells.Compared with the radiation alone group,the proportion of G2/M phase cells increased in radiation combined with drug group.Conclusions Artemisinin could reduce radiation-induced G2/M arrest and enhance the cytotoxicity of γ-irradiation on the CNE ceils.
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| 关 键 词： | 青蒿素 鼻咽癌 放射增敏 细胞周期 |
Radiosensitizing effects of artemisinin on CNE human nasopharyngeal carcinoma cells |
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| TANG yan,CAO Jian-ping,FAN Sai-jun,ZHU Wei,ZHANG Xu-guang,CHEN Xia-lin,JI Rong,PAN Chun-yan,ZHOU Yuan-yuan,FENG Yang,JIANG Qing.Radiosensitizing effects of artemisinin on CNE human nasopharyngeal carcinoma cells[J].Chinese Journal of Radiological Medicine and Protection,2009,30(6):280-282. |
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| Authors: | TANG yan CAO Jian-ping FAN Sai-jun ZHU Wei ZHANG Xu-guang CHEN Xia-lin JI Rong PAN Chun-yan ZHOU Yuan-yuan FENG Yang JIANG Qing |
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| Abstract: | |
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| Keywords: | ArtemisininNasopharyngeal carcinoma cellsRadiosensitizationCell cycle |
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