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非酒精性脂肪性肝病患者血清瘦素和脂联素与胰岛素抵抗的关系
引用本文:李异玲,杨淼,孟晓丹,贺小虎,王炳元.非酒精性脂肪性肝病患者血清瘦素和脂联素与胰岛素抵抗的关系[J].中华肝脏病杂志,2009,18(10):459-462.
作者姓名:李异玲  杨淼  孟晓丹  贺小虎  王炳元
作者单位:中国医科大学附属第一医院消化内科,沈阳,110001;
摘    要:Objective To investigate the serum leptin and adiponectin levels in nonalcoholic fatty liver disease (NAFLD) patients, and their relationship with insulin resistance. Methods A total of 120 cases were enrolled and divided into two groups: NAFLD group (n = 60) and normal control group (n = 60). The serum levels of leptin and adiponectin were measured by EL1SA. The body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol (Tchol), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), fasting blood glucose (FBG) and HOMA-IR (homeostasis model assessment insulin resistance) were detected and analyzed. Results Compared with control group, the serum leptin level in NAFLD group was Significantly higher (12.37 ± 1.99) μg/Lvs (5.20 ± 1.03)μg/L,P<0.01], while the serum adiponectin level was significantly lower (12.69 ± 2.83) mg/L vs (22.83 ± 4.61) mg/L, P < 0.01]. HOMA-IR was also much higher in NAFLD group than that in control group(4.86 ± 0.63) vs (1.91 ± 0.41), P < 0.01]. Logistic regression analysis showed that leptin was positively correlated with WHR ( P = 8.175, P < 0.01), HOMA-IR ( P = 0.974, P < 0.01 ), FBG ( β = 0.564, P < 0.01). In contrast, adiponectin inversely associated with HOMA-IR ( β = -0.495, P < 0.01 ) and BMI ( β = -0.314, P < 0.01) respectively. Conclusions The increased serum leptin level and decreased serum adiponectin level in NAFLD patients independently associated with HOMA-IR.

关 键 词:脂肪肝    瘦素    脂联素    胰岛素抵抗    

The relationship of leptin and adiponectin with insulin resistance in nonalcoholic fatty liver disease
LI Yi-ling,YANG Miao,MENG Xiao-dan,HE Xiao-hu,WANG Bing-yuan.The relationship of leptin and adiponectin with insulin resistance in nonalcoholic fatty liver disease[J].Chinese Journal of Hepatology,2009,18(10):459-462.
Authors:LI Yi-ling  YANG Miao  MENG Xiao-dan  HE Xiao-hu  WANG Bing-yuan
Abstract:
Keywords:Fatty liverLeptinAdiponectinInsulin resistance
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