| TX小鼠铜代谢和肝损害的实验研究 |
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| 引用本文： | 陈曦,王楚怀,丰岩清,汤其强,谢秋幼,梁崎,梁秀龄. TX小鼠铜代谢和肝损害的实验研究[J]. 中华肝脏病杂志, 2009, 17(7): 688-690. DOI: 10.3760/cma.j.issn.1007-3418.2009.09.012 |
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| 作者姓名： | 陈曦 王楚怀 丰岩清 汤其强 谢秋幼 梁崎 梁秀龄 |
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| 作者单位： | 中山大学附属第一医院康复医学科,广州,510080;中山大学附属第一医院神经内科,广州,510080;安徽省立医院神经内科;广州军区总医院高压氧科; |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金新教师课题2008年度中山大学医科青年教师科研启动基金国家自然科学基金广东省自然科学基金广东省医学科研课题 |
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| 摘 要： | Objective To provide right time points in selection of right aged animals and the normal physiological data of TX mice.Methods 7-12 months old TX and DL mice were studied,each group contained 3 female and 3 male mice of TX or DL mice.The concentration of copper in the serum,dry tissues (liver,brain and kidney),together with copper biochemistry indexes were measured.The liver histopathology was observed under light microscopy and electron microscope.Results Transaminase increased significantly only in 10 and 11-month-old(ASTX10=218.3 U/L,ASTTX11=197.5 U/L,ASTDL10=171.5 U/L,ASTDL11=165.0 U/L,P10＜0.001,P11=0.022),but the copper concentration of liver,brain and kidney was significantly increased dunng 7-1 2 month old(the average concentration of copper,LiverTX=(750.0±85.5)mg/kg,BrainTX=(39.7±2.2)mg/kg,KidneyTX=(29.8±5.0)mg/kg.LiverDL=(11.6±1.5)mg/kg,BrainDL=(16.8±0.9)mg/kg,KidneyDL=(14.2±1.0)mg/kg,t=21.16,23.60,7.47,for all these organs P＜0.05).Conclusion TX mice is a suitable model of liver disease with natural recovery,so selecting animal model of suitable time point is very important.
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| 关 键 词： | 肝疾病 小鼠 模型 动物 铜 |
Study of copper metabolism and liver damage in TX Mice-an animal model for liver disease |
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| Keywords: | Liver diseasesMiceModelsanimalCopper |
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