乙型肝炎病毒携带者的肝脏病理学与临床特征

Objective To study the relationship between liver pathology and clinical characters of chronic HBV carriers. Methods Analyze the age, sex, grade of liver inflammation and stage of liver fibrosis among patients with chronic HBV carriers (n= 58) and non-active HBsAg carriers (n= 32), and compare the grade of liver inflammation and stage of liver fibrosis in different groups according to age, ALT levels and with/without HBeAg. The data was processed by using t test or χ2 test for statistical analysis, respectively. Results (1) No differences existed in gender composition ratio between chronic HBV carriers and non-active HBsAg carriers. However, the ages of non-active HBsAg carriers group (35.2 7.6) were much older than that of the HBV carriers group (24.7 + 4.8) (t= 2.576, P= 0.017). (2) The stage of liver fibrosis in non-active HBsAg carriers group was more aggravated than that of the chronic HBV carriers group ( χ2= 23.231, P < 0.01), whereas no significant differences existed between these 2 groups (χ2= 0.058, P= 0.972). (3) As tothe grade of liver inflammation and the stage of liver fibrosis, significant differences existed between the groups with higher level of serum ALT (20-40 U/L) and lower level (≤ 20 U/L)( χ2= 7.827, P= 0.008; χ2= 14.303, P= 0.001), and similar results also exsited between elder group (>40) and younger group (≤ 40)( χ2= 10.949, P= 0.001; χ2= 21.271, P < 0.01); (4) Among the chronic HBV carriers, significant differences existed in grade of liver inflammation between groups with HBeAg positive and negative patients ( χ2= 10.275, P= 0.002), and the latter was more aggravated; however, there was no difference in stage of liver fibrosis between them (χ2= 3.457, P= 0.178). Conclusions Liver histopathology can be recommended to guide the clinical diagnosis and treatment, especially for the chronic HBV carriers, with elder age, ALT close to normal and HBeAg negative.

Relationship between liver pathology and clinical characters in HBV carriers