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| 慢性铅暴露小鼠海马细胞凋亡相关基因的表达 | |
| 引用本文： | 高明奇,陈航,周彬,张天彪,孙黎光,金心. 慢性铅暴露小鼠海马细胞凋亡相关基因的表达[J]. 中国公共卫生, 2005, 21(6): 688-689 |
| 作者姓名： | 高明奇 陈航 周彬 张天彪 孙黎光 金心 |
| 作者单位： | 1. 中国医科大学生物化学与分子生物学教研室,沈阳,110001 2. 中国医科大学机能实验中心 3. 沈阳医学院附属中心医院 4. 中国医科大学87期学生 |
| 基金项目： | 国家自然科学基金资助(39970651) |
| 摘 要： | 目的探讨发育期慢性铅暴露对小鼠海马B-细胞淋巴瘤/白血病-2基因(Bcelllymphoma/leukemia-2,bcl-2)和bcl-2相关X基因(bcl-2associateX,bax)mRNA表达的影响。方法用RT-PCR法检测慢性铅暴露时小鼠海马bcl-2和baxmRNA表达水平。结果慢性铅暴露可使小鼠脑海马bcl-2mRNA表达水平明显下降,而baxmRNA表达水平明显增加,与对照组比较差异有统计学意义(P<0.05)。结论慢性铅暴露可使小鼠脑海马bcl-2mRNA表达水平显著下降,而baxmRNA表达水平显著增加。 |
| 关 键 词： | 铅 海马 B-细胞淋巴瘤／白血病-2基因 bcx-2相关X基因 |
| 文章编号： | 1001-0580(2005)06-0688-02 |
| 修稿时间： | 2005-01-04 |
Expression of apoptosis-related gene in hippocampus of mice after chronic lead exposure |
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| GAO Mingqi,CHEN Hang,ZHOU Bin,et al.. Expression of apoptosis-related gene in hippocampus of mice after chronic lead exposure[J]. Chinese Journal of Public Health, 2005, 21(6): 688-689 | |
| Authors: | GAO Mingqi CHEN Hang ZHOU Bin et al. |
| Affiliation: | GAO Mingqi,CHEN Hang,ZHOU Bin,et al.Department of Biochemistry and Molecular Biology,Basic Medical College,China Medical university |
| Abstract: | Objective To explore the effect of chronic lead exposure on the mRNA expression of bcl-2 and bax in hippocampus of mice.Methods RT-PCR techniques were applied to recognize either the mRNA expression of bcl-2 and bax in hippocampus of mice exposed to low level of lead.Results Bcl-2 mRNA expression in Pb 2+-exposed group exhibited a significantly decline and bax mRNA expression in Pb 2+-exposed group exhibited a significantly increase compared with control group.Conclusion Chronic lead exposure results in significant decline of bcl-2 mRNA expression and significantly increase of bax mRNA expression in hippocampus of mice. |
| Keywords: | lead hippocampus bcl-2 bax |
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