5-Hydroxytryptamine stimulates the release of prostacyclin but not thromboxane A2 from isolated rat dental pulp |
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| Authors: | M Hirafuji Y Ogura |
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| Affiliation: | 1. Laboratoire de Biomathématiques, Biophysique, Biochimie et Scientométrie, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000, Bejaia, Algeria;2. Analytical Chemistry Research Group (FQM-323), Department of Physical and Analytical Chemistry, University of Jaén, Campus Las Lagunillas, Edificio B-3, 23071, Jaen, Spain;3. Foodomics Laboratory, Bioactivity and Food Analysis Department, Institute of Food Science Research CIAL (UAM-CSIC), Campus de Cantoblanco, Calle Nicolás Cabrera 9, 28049, Madrid, Spain;1. General Practice, Monash University, Victoria;2. Family Medicine Research Centre, The University of Sydney, New South Wales;3. The Judith Lumley Centre, La Trobe University, Victoria;4. ACT Medicare Local, Australian Capital Territory;5. Centre for Medicine Use and Safety, Monash University, Victoria |
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| Abstract: | The effect of 5-hydroxytryptamine (5-HT) on the release of prostacyclin and thromboxane (TX) A2 from isolated rat dental pulp was evaluated. 5-HT (1-1,000 microM) caused a dose-dependent and marked stimulation of the release of prostacyclin but not TXA2. Of the 5-HT-related indolealkylamines tested, only tryptamine had a similar stimulatory effect while tryptophan and 5-hydroxytryptophan had no effect. Neither histamine (100 microM) nor bradykinin (100 microM) had such an effect. Our results suggest the possible involvement of 5-HT receptors in 5-HT-induced stimulation of prostacyclin production in rat dental pulp. |
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