| 雌激素受体与原发胆囊癌临床病理关系的研究 |
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| 引用本文： | 陈汝福,邹声泉.雌激素受体与原发胆囊癌临床病理关系的研究[J].肝胆外科杂志,1999,7(4):312-313. |
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| 作者姓名： | 陈汝福 邹声泉 |
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| 作者单位： | 同济医科大学附属同济医院普外科!武汉430030 |
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| 摘 要： | 目的 探讨雌激素受体（ＥＲ）与原发胆癌临床病理间的关系。方法 应用免疫组化技术对３６例原发胆囊癌组织中的雌激素受体进行了检测。结果 ３６例原发胆囊癌组织（ＥＲ）阳性表达率为６３．９％，ＥＲ一的胆囊癌ＰＣＮＡ指数显著高于阴性者；ＥＲ阳性与原发胆囊癌的分化程度、侵袭转移密切相关；ＥＲ阳性者胆囊患者的累计生存率低于ＥＲ阴性者，结论ＥＲ阳性的原发胆囊癌有较差的生物学行为和预后。
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| 关 键 词： | 胆囊癌 雌激素受体 这临床病理 |
ESTROGEN RECEPTOR EXPRESSION AND ITS RELATION WITH CLINICOPATHOLOGIC FEATURE IN GALLBLADDER CARCINOMA |
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| Chen Rufu,Zou Shengquan.ESTROGEN RECEPTOR EXPRESSION AND ITS RELATION WITH CLINICOPATHOLOGIC FEATURE IN GALLBLADDER CARCINOMA[J].Journal of Hepatobiliary Surgery,1999,7(4):312-313. |
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| Authors: | Chen Rufu Zou Shengquan |
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| Institution: | Chen Rufu,Zou Shengquan Department of General Surgery,Tongji Hospital,Tongji Medical Uinversity,Wuhan 430030 |
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| Abstract: | Objective To investigate the clinicopathologic significance of estrogen recepter(ER) in galladder carcinoma.Methods ER and PCNA were detected in 36 cases of gallbladder cacinomas with immunohistochemical stain.Result Expression rate of ER in tumor tissue was found in 63.9%(23/36) of patients,The PCNA labled index in ER positive gallbladder carcinoma was significanly lower than that in ER negtive gallbladder carcinoma,(P<0.01);ER positively correlated with differentiation,invassion,metastasis and nevin stage (P<0.05),ER positive group showed significantly decreased surrival rae than that in ER gentive group (P<0.05).Conclusion ER negtive gallbladder carcinoma had less malignant biogial behavior and better prgnosis thannegtive gallbladder carcinoma. |
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| Keywords: | Gallbladder carcinoma Estrogen receptor PCNA |
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