| 混合透皮促渗剂对阿斯匹林凝胶剂透皮吸收作用的影响 |
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| 引用本文： | 杨唐玉,易以木. 混合透皮促渗剂对阿斯匹林凝胶剂透皮吸收作用的影响[J]. 华中科技大学学报(医学版), 2001, 30(6): 533-534 |
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| 作者姓名： | 杨唐玉 易以木 |
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| 作者单位： | 华中科技大学同济医学院药学院药剂教研室,武汉,430030 |
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| 基金项目： | 卫生部科学研究基金资助项目(No.94-2-098) |
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| 摘 要： | 制备阿斯匹林凝胶剂,比较了不同浓度的月桂氮卓酮和薄荷脑对阿斯匹林透皮吸收的影响.结果发现以l%的月桂氮卓酮(AZ)加1%的薄荷脑(MT)作为吸收促渗剂的3号处方中阿斯匹林的吸收最好,体外释放速度符合Hignchi方程.提示适当浓度的AZ和MT能明显促进阿斯匹林的透皮吸收.但阿斯匹林和MT的浓度过高促透效果迟缓.
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| 关 键 词： | 阿斯匹林 凝胶剂 透皮吸收 |
| 修稿时间： | 2001-05-21 |
The effect of Mixed Transdermal Enhancers on Percutaneous Absorption of Asprin Gel |
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| Yang Tangyu,Yi Yimu. The effect of Mixed Transdermal Enhancers on Percutaneous Absorption of Asprin Gel[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2001, 30(6): 533-534 |
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| Authors: | Yang Tangyu Yi Yimu |
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| Affiliation: | Yang Tangyu,Yi Yimu Department of Pharmaceutics,College of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | The effect of mixed transdermal enhancers of azone and menthol on percutaneous absorption of asprin was investigated. Modified Franz diffusion cells and isolated mice abdomen skin were used in the drug penetration tests. The transdermal amount of asprin in different concentrations of mixed azone and menthol was determinded. Comparison of asprin gel having no azone and menthol with the gel containing different azone and menthol concentrations of 0.5 %, 1.5 %, 2 % and 2.5 % showed a remarkable difference ( P <0.05) after 2 h. Comparison of asprin gel without azone and menthol with the gels containg 1 % azone and menthol showed a remarkable difference ( P <0.01). It was demonstrated that various transdemal enhances could promote the absorption of asprin in different levels and 1 % azone plus 1 % menthol was the most effective one. |
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| Keywords: | asprin azone menthol transdermal absorption |
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