乳腺癌X射线征象与雌激素受体、孕激素受体和C-erbB-2表达相关性的研究进展

乳腺癌是女性最常见的恶性肿瘤之一，其发生、发展过程中大多伴随基因异常表达。雌激素受体（ER）、孕激素受体（PR）及C—erbB-2（即人表皮生长因子受体2）癌基因的表达情况是指导临床内分泌治疗及判断预后的主要参考指标。癌基因表达从不同角度反映了乳腺癌的恶性生物学行为，并引起组织病理学改变，进而形成多种影像学表现。因此，乳腺癌的X射线片表现可在一定程度上反映ER、PR和C-erbB-2的表达情况。乳腺X射线检查因诊断病变的准确率高、操作简单、价格低廉，仍是临床筛查及诊断乳腺癌的首选方法，并成为预测乳腺癌患者ER、PR和c—erbB-2表达情况的无创手段。在无条件做免疫组化的情况下，它对乳腺癌术前评估及非手术治疗发挥了重要作用，具有潜在的临床应用价值。该文主要对乳腺癌影像学表现与ER、PR和CIerbB-2表达的相关性研究进行综述。

Development of the correlation study between mammographic appearances and expression of estrogen receptor, progesterone receptor and C-erbB-2 in patients with breast cancer

Breast cancer is one of the most common female malignant tumors. The occurrence and development of breast cancer are often accompanied by abnormal gene expression. It has been well accepted that estrogen receptor （ER）, progesterone receptor （PR） and C-erbB-2 （epidermal growth factor receptor -2） are the main reference indexes for clinical endocrine therapy and prognosis prediction. Oncogene expression reflects the malignant biological behavior of breast cancer from different perspectives. Those aggressive behaviors cause a variety of changes in histopathology and thus in imaging. Therefore, the imaging features of breast cancer may indirectly demonstrate the status of ER, PR and C-erbB-2 to a certain extent. Until now, because of its simple operation, low cost and high accuracy, mammography is still the preferred method in breast cancer screening and diagnosis, and has been proposed as a noninvasive technique for prediction of the expression of ER, PR and C-erbB-2. It has potential clinical value in preoperative assessment and non- surgical treatment for those who are not able to perform immunohistochemistry. This review summarized pre- vious related studies and explored mammography as a noninvasive predictor for ER, PR and C-erbB-2.