放射增敏剂尼可胺对雄性大鼠生殖毒性的研究

目的 观察尼可胺对雄性大鼠生殖能力的影响。 方法 将100只健康成年雄性Wistar大鼠随机分为4组：空白对照组（0.9%氯化钠注射液）、尼可胺高剂量组（300 mg/kg）、尼克胺中剂量组（200 mg/kg）和尼克胺低剂量组（100 mg/kg）。雄性大鼠连续尾静脉注射给药5周后（每日1次），与100只雌性Wistar大鼠随机1:1合笼交配，交配后处死雄性大鼠，检查尼可胺对各剂量组雄性大鼠的交配率、精子数量、精子活率、精子活力、脏器系数的影响及睾丸、附睾的组织病理学变化。 结果 200 mg/kg以下剂量对成年雄性大鼠检测的生育指标无明显影响。 结论 200 mg/kg以下剂量对成年雄性大鼠的生殖功能无明显毒性作用。

The reproductive toxicity of NiKeAn in male rats

Objective To observe the toxic effects of NiKeAn on the ability of reproduction in male rats. Methods One hundred health adult Wistar rats were randomly divided into 4 groups with 25 in each group. The rats of control groups were given intravenous injections with normal saline and the experimental groups received NiKeAn at doses of 300 mg/kg, 200 mg/kg and 100 mg/kg once per day. All rats were injected for 5 weeks then mated and executed. The coefficient of testicle and epididymis, mating rate, sperm, the per- centage of motile sperm, and histopathological changes of testicle and cpididymis were detected. Results Under doses of 200 mg/kg concentration of NiKeAn used in this study have no significant influence on the aforementioned parameters. Conclusion Under doses of 200 mg/kg, reproductive function of male rats does not obviously impaired by NiKeAn.