国产坎地沙坦对高血压病患者内皮功能及胰岛素抵抗的影响

目的:探讨国产坎地沙坦对高血压病患者内皮功能及胰岛素抵抗的影响.方法:42例高血压病患者口服坎地沙坦8周,治疗前、后采静脉血测定空腹血糖、胰岛素计算胰岛素敏感指数,同时测定血浆内皮素-1、一氧化氮水平的变化.结果:坎地沙坦治疗高血压病12周后患者的收缩压和舒张压均降低,空腹胰岛素敏感指数均较前显著升高,血浆一氧化氮显著升高而内皮素-1显著降低.结论:坎地沙坦能有效降压和改善胰岛素抵抗及血管内皮功能.

Effects of domestic candesartan on endothelial function and insulin resistance in essential hypertension patients

Objective:To investigate the effects of candesartan on endothelial function and insulin resistance in essential hypertension patients.Methods:The concentrations of fasting blood glucose, serum insulin were measured in 42 patients with hypertension after 8 weeks treatment with candesartan. Endothelial function was assessed by the concentration of plasma endothelin-1(ET-1) nitric oxide(NO) measured before and after treatment.Results: After 8 weeks treatment with candesartan,SBP and DBP decreased significantly. Fast insulin was reduced and insulin sensitive index was significantly increased. Candesartan also resulted in a significant reduction of plasma ET-1 and a rise of nitric oxide(NO)(P<0.05,P<0.01 respectively).Conclusion: Candesartan can effectively decrease blood pressure and improve endothelial function and insulin resistance.