| 胆红素脑病仔兔脑组织单胺类神经递质含量变化的研究 |
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| 引用本文： | 文香淑,李晓捷,郭丽,李林,姜志梅.胆红素脑病仔兔脑组织单胺类神经递质含量变化的研究[J].中国康复,2001,16(1):1-3. |
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| 作者姓名： | 文香淑 李晓捷 郭丽 李林 姜志梅 |
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| 作者单位： | 黑龙江省小儿脑瘫防治疗育中心(佳木斯市 154003) |
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| 基金项目： | 黑龙江省科学技术计划项目(G99 C22-4) |
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| 摘 要： | 目的 以动物实验方法制备胆红素脑病模型，观察脑组织单胺类神经质的变化，研究单胺递质与胆红素神经毒性的相互关系。方法 取生后2-5d内的纯种仔兔，向腹腔内注射胆红素，制备胆红素脑病模型，测定脑组织内单胺递质的浓度。结果 胆红素脑病仔兔脑组织多巴胺及5-羟色胺含量升高，去甲肾上腺素含量下降，与对照组比较差异有显著性，但无时间剂量相关性。结论 胆红素脑病仔兔脑组织单胺递质变化与胆红素神经毒素有关。
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| 关 键 词： | 胆红素脑病 脑组织 单胺类神经递质 动物模型 |
| 文章编号： | 1001-2001(2001)01-0001-03 |
| 修稿时间： | 2000年11月15 |
The Changes of Monomine in the Rabbits with Bilirubin-induced Encephalopathy |
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| Wen Xiangshu,Li Xiaojie,Guo Li,et al..The Changes of Monomine in the Rabbits with Bilirubin-induced Encephalopathy[J].Chinese Journal of Rehabilitation,2001,16(1):1-3. |
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| Authors: | Wen Xiangshu Li Xiaojie Guo Li |
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| Institution: | Wen Xiangshu,Li Xiaojie,Guo Li,et al. Cerebral Hemiplegia Sanitarium Center of Helongjiang Province,Jiamushi 154003 |
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| Abstract: | Objective To observe the changes of monomine in brain and to study the relationship between monomine and bilirubin neurotoxicity. Methods A model of bilirubin induced encephalopathy was developed. The newborn rabbits at age of 2 to 5 days were subjected to the injection of bilirubin intraperineally and then sacrificed to determine the bilirubin concentration of serum and brain and monomine levels of brain tissue. Results The levels of dopamine (DA) and 5 HT were increased and NE decreased in the brain tissue of the rabbits with bilirubin induced encephalopathy as compared with control group, but were not related with bilirubin concentration and time of exposure. Conclusion The changes in monomine in the brain tissue of the rabbits with bilirubin induced encephalopathy were related to the bilirubin neurotoxicity. |
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| Keywords: | bilirubin-induced encephalopathy brain tissue monomine animal model |
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