| PAI-1基因4G/5G多态性与特发性肺纤维化的相关性研究 |
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| 引用本文： | 徐雪艳,郑培华,管立学,李海波,刘志翠,吴立平.PAI-1基因4G/5G多态性与特发性肺纤维化的相关性研究[J].中国优生与遗传杂志,2010(4):24-25. |
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| 作者姓名： | 徐雪艳 郑培华 管立学 李海波 刘志翠 吴立平 |
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| 作者单位： | 潍坊市人民医院干细胞实验室;诸城市人民医院; |
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| 摘 要： | 目的探讨纤溶酶原激活剂抑制物-1（plasminogen activator inhibitor-1,PAI-1）基因启动子区4G/5G多态性与特发性肺纤维化（IPF）的相关性。方法应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析,检测42例IPF患者和164例正常对照组人群PAI-1基因4G/5G多态性。结果PAI-1基因4G/4G、4G/5G、5G/5G基因型频率分布,IPF组分别为31.0%、50.0%、19.0%,对照组分别为17.1%、54.9%、28.0%;4G和5G等位基因频率,IPF组分别为0.560和0.440,对照组分别为0.445和0.555;4G/4G基因型频率IPF组显著高于对照组（P〈0.05）。与4G/5G和5G/5G基因型比较,携带4G/4G型个体发生IPF的风险增加2.18倍,95%CI：1.02～4.68（P〈0.05）。结论PAI-1基因4G/5G多态性与IPF的发病相关,纯合子4G/4G基因型可能是IPF发病的重要危险因素之一。
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| 关 键 词： | 特发性肺纤维化 纤溶酶原激活剂抑制物-1 多态现象 |
Relationship between the 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and idiopathic pulmonary fibrosis |
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| XU Xue-yan,ZHENG Pei-huan,GUAN Li-xue,et al..Relationship between the 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and idiopathic pulmonary fibrosis[J].Chinese Journal of Birth Health & Heredity,2010(4):24-25. |
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| Authors: | XU Xue-yan ZHENG Pei-huan GUAN Li-xue |
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| Institution: | XU Xue-yan,ZHENG Pei-huan,GUAN Li-xue,et al.(Laboratory of Stem Cell,Weifang People\'s Hospital Affiliated to Weifang Medical College,261041) |
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| Abstract: | Objective:To investigate the relationship between polymorphism of plasminogen activator inhibitor-1(PAI-1)gene 4G/5G and idopathic pulmonary fibrosis(IPF) in Weifang population.Methods:In this case-control study,the PAI-1 gene 4G/5G polymorphism was determined by PCR-RFLP in 42 IPF patients and 164 normal controls from the rural area of Weifang. Results:The frequencies of PAI-1 gene 4G/4G,4G/5G and 5G/5G genotypes were 31.0%,50.0% and 19.0%,respectively in IPF group,and 17.1%,54.9% and 28.0%,respectively in... |
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| Keywords: | Idiopathic pulmonary fibrosis Plasminogen activator inhibitor-1 Polymorphism |
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