实验性急性肺血栓栓塞症肺动脉血管重构及意义

目的：探讨急性肺血栓栓塞症肺动脉血管重构及其临床意义。方法：取栓塞3～24h后的急性肺血栓栓塞症动物模型的栓塞段肺动脉，同时取正常肺动脉设实验对照组，固定液固定后送检。结果：正常肺动脉内皮细胞完整，未见平滑肌细胞迁移，肌层平滑肌呈层状，多为收缩型；肺栓塞后，肺动脉内皮细胞脱落，中层平滑肌细胞向内皮迁移，可见较多的合成型平滑肌细胞，内皮下可见类凋亡平滑肌细胞。结论：急性肺栓塞后，栓塞段肺动脉局部发生血管重构．对肺动脉高压的产生可能起着一定作用。

The Clinical Significance of Pulmonary Vessel Remodel after Experimental Acute Pulmonary Embolism in Rabbits

Objective: To study the pulmonary artery remodel and its clinical significance after experimental acute pulmonary embolism (APE) in rabbits. Methods: After establishing the model of acute pulmonary embolism in rabbits, the specimens were obtained in both normal and lesion pulmonary artery at 3 h, 8 h and 24 h of APE. Results: The endothelium cells were integrity in normal pulmonary artery.There was less migration of smooth muscle cell, which displayed in layers and formed systolic style. After experimental acute pulmonary embolism, a large amount of endothelial cells were denudated, lots of smooth muscle cells migrated to endothelium layer, and more of them showed synthetic style. There were some para-apoptosis cells. Conclusion: The vessel remodel does exist in thrombo-embolism pulmonary artery after acute pulmonary embolism, which may lead to high pressure in pulmonary artery.