尿激酶溶栓治疗不稳定心绞痛疗效观察

目的：对比尿激酶（UK）与肝素治疗不稳定心绞痛（UA）中的疗效。方法：采用有对照完全随机化方法。小剂量尿激酶溶栓前增加静脉扒注3000^U肝素。观察两组心绞痛发作，30天病死率和急性心肌梗塞（AMI）发生率。结果：小剂量尿激酶（UK）组在心脏事件（死亡 AMI例数）的发生率低于肝素组，减少频发心绞痛发生率优于肝素组。结论：小剂量尿激酶溶栓前加强抗凝血酶治疗，在降低频发心绞痛发生率、30天内AMI发生率和病死率优于肝素组。

Clinical effect of urokinase thrombolysis in unstable angina

Absrtact:Objective:To evaluate the clinical effect of urokinase(UK)in unstable angina(UK).Methods:This was a placebo-controlled randomized clinical trial.In law-dose UK group heparin 3000U iv before thrombolylic therapy. Attack of angina incidences mortity of AMI within 30 days was monitired between the thrombolylic and control groups.Results:In low-does UK group mortity of cariacevent and incidenses of AMI were lower and the number of patient with frequent anigina was significant decrease than the control group.Conclusion:In law-dose UK group enhancing antithrombin therapy before thrombolylic therapy reduced the rate of attack of frequent angia and AMI morthly within 30 days.