| 赤雹果总有机酸对大鼠离体子宫平滑肌的作用及机制研究 |
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| 引用本文： | 赵盼,佟继铭,刘玉玲,宋素英.赤雹果总有机酸对大鼠离体子宫平滑肌的作用及机制研究[J].中国实验方剂学杂志,2013,19(8):202-205. |
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| 作者姓名： | 赵盼 佟继铭 刘玉玲 宋素英 |
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| 作者单位： | 1. 河北联合大学中医学院,河北唐山,063000
2. 承德医学院中药研究所,河北承德,067000 |
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| 基金项目： | 河北省自然科学基金资助项目(C2006000863) |
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| 摘 要： | 目的:观察赤雹果总有机酸(FTDBP)对大鼠离体子宫平滑肌活力的影响.方法:选用8周龄Wistar雌性未孕大鼠,以子宫平滑肌的收缩频率、收缩幅度指标,计算子宫平滑肌活力及FTDBP的半数抑制浓度(IC50).以盐酸普萘洛尔、盐酸苯海拉明、盐酸雷尼替丁、硫酸阿托品为阻断剂,观察FTDBP对子宫平滑肌作用与β,H1,H2,M受体的关系,探讨FTDBP对子宫平滑肌的作用机制.结果:与模型组比较,FTDBP剂量组(0.032,0.064,0.128 g·L-1)和元胡止痛片组对缩宫素所致大鼠离体子宫平滑肌的收缩频率、收缩幅度和活力均有明显的抑制作用(P＜0.05或P＜0.01),IC50为0.100 24 g·L-1；与模型组比较,硫酸阿托品组大鼠子宫平滑肌的收缩频率、幅度和活力差异无统计学意义.结论:FTDBP对大鼠子宫平滑肌活力有明显的抑制作用,其作用是通过抑制M受体实现的,与H1,H2,β受体无关.
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| 关 键 词： | 赤雹果 总有机酸 受体 子宫收缩 |
| 收稿时间： | 8/3/2012 12:00:00 AM |
Effect of Total Organic Acid of Thladiantha dubia on Active Capacity of Isolated Rat Uterine Smooth Muscle in vitro |
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| ZHAO Pan,TONG Ji-ming,LIU Yu-ling and SONG Su-ying.Effect of Total Organic Acid of Thladiantha dubia on Active Capacity of Isolated Rat Uterine Smooth Muscle in vitro[J].China Journal of Experimental Traditional Medical Formulae,2013,19(8):202-205. |
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| Authors: | ZHAO Pan TONG Ji-ming LIU Yu-ling and SONG Su-ying |
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| Institution: | College of Chinese Medicine of Hebei Unite University, Tangshan 063000, China;Institue of Chinese Materia Medica of Chengde Medical College, Chengde 067000, China;Institue of Chinese Materia Medica of Chengde Medical College, Chengde 067000, China;College of Chinese Medicine of Hebei Unite University, Tangshan 063000, China |
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| Abstract: | |
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| Keywords: | Thladiantha dubia Total Organic acid receptor uterine contraction |
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