| 健脾益气活血汤对自发性高血压大鼠血管内皮舒缩因子表达的影响 |
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| 引用本文： | 曲怡,张立德,陈志娟,王珊珊,谷丽艳,林庶茹.健脾益气活血汤对自发性高血压大鼠血管内皮舒缩因子表达的影响[J].中国实验方剂学杂志,2013,19(8):221-224. |
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| 作者姓名： | 曲怡 张立德 陈志娟 王珊珊 谷丽艳 林庶茹 |
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| 作者单位： | 辽宁中医药大学基础医学院中医分子生物学实验室,沈阳,110847 |
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| 基金项目： | 辽宁省科技厅自然科学基金计划项目(20102150) |
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| 摘 要： | 目的:观察健脾益气活血汤对自发性高血压大鼠(SHR)收缩压及血管内皮舒缩因子表达的影响.方法:采用随机对照方法,将60只24周龄SHR分为SHR组(给予蒸馏水)、培哚普利组(培哚普利,0.4 mg·kg-1·d-1)、培哚普利联合中药组(培哚普利0.4 mg·kg-1·d-1+中药健脾益气活血汤20 g·kg-1·d-1,ig,中加西组)、健脾益气活血汤高、中、低剂量组(40,20,10 g·kg-1 ·d-1,ig),每组10只,以同龄同种系正常血压的京都种大鼠(WKY)10只作为WKY组(给予蒸馏水).BP-98A型智能无创血压计监测大鼠尾动脉收缩压变化；治疗6周后腹主动脉取血测定血浆一氧化氮(NO)、前列环素(PGI2)、内皮源性超极化因子(EDHF)、血管紧张素Ⅱ(AngⅡ)、内皮素l(ET-1)浓度.结果:与SHR组收缩压(207.5±16.7) mmHg相比,培哚普利组(165.8±10.2)mmHg,中加西组(160.4 ±16.5) mmHg明显降低(P＜0.01).SHR组血浆NO(5.3±.1.6) μmol·L-1,PGI2(27.2±6.3) ng·L-1、EDHF(106.7±3.2) ng·L-1浓度低于WKY组(33.8 ±7.5) μmol·L-1,(842.9 ±218.6),(347.0±44.4) ng·L-1,(P＜0.01)；培哚普利组、中加西组、中药高、中剂量组血浆NO,PGI2,EDHF浓度高于SHR组；SHR组大鼠血浆ET-1 (77.1±13.9) ng·L-1,AngⅡ(21.0±2.6)μg·L-1浓度高于WKY组(20.8±1.9) ng·L-1,(1.1±0.3) ng·L-1,(P＜0.05)；培哚普利组、中加西组、中药高、中、低剂量各组大鼠血浆ET-1,AngⅡ浓度明显低于SHR组,(P＜0.01).结论:健脾益气活血汤可调控血管内皮舒缩因子的分泌与释放平衡,改善血管内皮功能,降低收缩压,减轻血压增高引起的血管内皮功能障碍.
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| 关 键 词： | 健脾益气活血汤 自发性高血压大鼠 血管内皮舒张因子 血管内皮收缩因子 |
| 收稿时间： | 2012/9/25 0:00:00 |
Influence of Jianpi Yiqi Huoxue Decoction on Vasomotor Factors Expression in Vascular Endothelium of Spontaneously Hypertensive Rats |
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| QU Yi,ZHANG Li-de,CHEN Zhi-juan,WANG Shan-shan,GU Li-yan and LIN Shu-ru.Influence of Jianpi Yiqi Huoxue Decoction on Vasomotor Factors Expression in Vascular Endothelium of Spontaneously Hypertensive Rats[J].China Journal of Experimental Traditional Medical Formulae,2013,19(8):221-224. |
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| Authors: | QU Yi ZHANG Li-de CHEN Zhi-juan WANG Shan-shan GU Li-yan and LIN Shu-ru |
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| Institution: | Chinese Medical Science Molecular Biology laboratory of the Basic Medical College of the Traditional Chinese Medicine of Liaoning University, Shenyang 110847, China;Chinese Medical Science Molecular Biology laboratory of the Basic Medical College of the Traditional Chinese Medicine of Liaoning University, Shenyang 110847, China;Chinese Medical Science Molecular Biology laboratory of the Basic Medical College of the Traditional Chinese Medicine of Liaoning University, Shenyang 110847, China;Chinese Medical Science Molecular Biology laboratory of the Basic Medical College of the Traditional Chinese Medicine of Liaoning University, Shenyang 110847, China;Chinese Medical Science Molecular Biology laboratory of the Basic Medical College of the Traditional Chinese Medicine of Liaoning University, Shenyang 110847, China;Chinese Medical Science Molecular Biology laboratory of the Basic Medical College of the Traditional Chinese Medicine of Liaoning University, Shenyang 110847, China |
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| Abstract: | |
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| Keywords: | Jianpi Yiqi Huoxue decoction spontaneously hypertensive rats vascular endothelial diastolic factor vascular endothelial systolic factor |
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