星点设计-效应面法优化熊果酸自微乳给药系统

目的:采用星点设计-效应面法优化熊果酸自微乳化给药系统.方法:以乳化剂与助乳化剂的比例和含油量为考察因素,微乳粒径、饱和载药量为效应值,采用SAS 9.1.3软件筛选最优处方,并进行验证.结果:熊果酸自微乳的优化处方为油相(MCT)-乳化剂(HS15)-助乳化剂(alcohol) 12.5∶62.5∶25.结论:应用星点设计-效应面法能方便准确地得到熊果酸自微乳化给药系统的较优处方,所建立的模型预测性良好.

Optimization of Self-microemulsion Drug Delivery System of Ursolic Acid by Central Composite Design/Response Surface Methodology

Objective: To optimize formulation of ursolic acid self-microemulsion drug delivery system using central composite design/response surface methodology. Method: With ratio of surfactants and cosurfactants and oil content as independent variables,particle size and saturated drug doading were taken as dependent variables,optimum formulation was screened by SAS9.1.3 software,and verified. Result: Optimized formulation of ursolic acid self-microemulsion was oil phase(MCT)-emulsifier(HS15)-cosurfactants(alcohol) 12.5:62.5:25. Conclusion: This optimized formulation of ursolic acid self-microemulsion drug delivery system could be obtained exactly and conveniently by central composite design response surface methodology,and established model had a reliable predictability.