| 赤雹根总皂苷对类风湿性关节炎大鼠血清OPG/RANKL水平的影响 |
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| 引用本文： | 邹君,刘永平,顾士栋,阎昊,佟继铭. 赤雹根总皂苷对类风湿性关节炎大鼠血清OPG/RANKL水平的影响[J]. 中国实验方剂学杂志, 2013, 19(8): 218-220 |
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| 作者姓名： | 邹君 刘永平 顾士栋 阎昊 佟继铭 |
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| 作者单位： | 河北省中药研究与开发重点实验室,承德医学院中药研究所,河北承德067000 |
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| 基金项目： | 河北省自然科学基金项目(C200600863);河北省教育厅重大项目(ZD2010131) |
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| 摘 要： | 目的:观察赤雹根总皂苷(TSTR)对佐剂性关节炎(AA)模型大鼠血清骨保护素(OPG)、核因子-κB受体活化因子配体(RANKL)表达水平的影响,探讨TSTR治疗类风湿性关节炎的机制.方法:SD大鼠,随机取10只作为空白对照,其余大鼠采用弗氏完全佐剂制备关节炎模型,将造模成功的关节炎大鼠随机分为模型对照组、TSTR 40,80,160 mg·kg-1·d-1剂量组、雷公藤多苷12 mg·(kg·d)-1阳性对照组.各组分别ig给予相应的药物,模型对照组ig等容积的水.连续ig给药21 d后处死.采用ELISA法检测血清OPG,RANKL水平.结果:TSTR各剂量组大鼠血清RANKL水平分别为(98.74 ±10.17),(87.81±17.78),(77.75±14.61) pmol·L-1,均显著低于模型组(120.80±12.14) pmol·L-1(P ＜0.05或P＜0.01)；TSTR各剂量组血清OPG水平分别为(71.67 ±2.62),(77.50 ±0.93),(91.04±7.26) pmol·L-1,均显著高于模型组(53.64 ±3.46)pmol·L-1(P＜0.05或P＜0.0l)；TSTR各剂量组OPG/RANKL比值分别为0.71 ±0.08,0.89±0.17,1.13 ±0.24,显著高于模型对照组0.43±0.06(P＜0.05或P＜0.01).结论:TSTR可能通过影响OPG/RANKL系统而对破骨细胞功能产生影响,从而防治骨破坏.
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| 关 键 词： | 赤雹根总皂苷 类风湿性关节炎 骨保护素 核因子-κB受体活化因子配体 |
| 收稿时间： | 2012-09-12 |
Effect of Saponins from Thladiantha dubia Roots on Levels of OPG/RANKL in Serum of Rat with Rheumatoid Arthritis |
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| ZOU Jun,LIU Yong-ping,GU Shi-dong,YAN Hao and TONG Ji-ming. Effect of Saponins from Thladiantha dubia Roots on Levels of OPG/RANKL in Serum of Rat with Rheumatoid Arthritis[J]. China Journal of Experimental Traditional Medical Formulae, 2013, 19(8): 218-220 |
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| Authors: | ZOU Jun LIU Yong-ping GU Shi-dong YAN Hao TONG Ji-ming |
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| Affiliation: | Key Laboratory of Study and Exploiture for New Drugs of Traditional Chinese Medicine(TCM), Institute of TCM Medica of Chengde Medical College, Chengde 067000, China;Key Laboratory of Study and Exploiture for New Drugs of Traditional Chinese Medicine(TCM), Institute of TCM Medica of Chengde Medical College, Chengde 067000, China;Key Laboratory of Study and Exploiture for New Drugs of Traditional Chinese Medicine(TCM), Institute of TCM Medica of Chengde Medical College, Chengde 067000, China;Key Laboratory of Study and Exploiture for New Drugs of Traditional Chinese Medicine(TCM), Institute of TCM Medica of Chengde Medical College, Chengde 067000, China;Key Laboratory of Study and Exploiture for New Drugs of Traditional Chinese Medicine(TCM), Institute of TCM Medica of Chengde Medical College, Chengde 067000, China |
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| Abstract: | |
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| Keywords: | saponins from Thladiantha dubia roots rheumatoid arthritis OPG RANKL |
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