| 运用近红外技术建立藿香正气胶囊中厚朴酚的定量模型 |
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| 引用本文： | 郭念欣,蔡佳良,李蕾蕾,黄洁燕,姬生国.运用近红外技术建立藿香正气胶囊中厚朴酚的定量模型[J].中国实验方剂学杂志,2013,19(8):146-149. |
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| 作者姓名： | 郭念欣 蔡佳良 李蕾蕾 黄洁燕 姬生国 |
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| 作者单位： | 广东药学院中药学院,广州,510006 |
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| 摘 要： | 目的:采用近红外光谱技术建立藿香正气胶囊中厚朴酚含量快速测定的方法.方法:以高效液相色谱法测定109批次藿香正气胶囊中厚朴酚含量,近红外光谱法采集近红外光谱数据,结合偏最小二乘法(PLS)建立厚朴酚的定量模型.结果:建立的厚朴酚校正模型相关系数(R2)、内部交叉验证均方差、校正均方差分别为0.945 6,0.054 3,0.024 5.经外部验证,预测均方差为0.045 9,平均回收率为101.26％.结论:建立的近红外定量模型稳定,准确可靠,可快速对藿香正气胶囊中厚朴酚的含量进行测定.
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| 关 键 词： | 近红外光谱法 藿香正气胶囊 厚朴酚 高效液相色谱法 |
| 收稿时间： | 2012/5/31 0:00:00 |
Determination content of Magnolol in Huoxiang Zhengqi Capsules Separate from Different Pharmaceutical Factories by Near-infrared Spectroscopy |
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| GUO Nian-xin,CAI Jia-liang,LI Lei-lei,HUANG Jie-yan and JI Sheng-guo.Determination content of Magnolol in Huoxiang Zhengqi Capsules Separate from Different Pharmaceutical Factories by Near-infrared Spectroscopy[J].China Journal of Experimental Traditional Medical Formulae,2013,19(8):146-149. |
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| Authors: | GUO Nian-xin CAI Jia-liang LI Lei-lei HUANG Jie-yan and JI Sheng-guo |
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| Institution: | School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China |
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| Abstract: | Objective: To determine the content of Magnolol in Huoxiang Zhengqi capsules by near-infrared spectroscopy(NIR). Method: Determined the content of magnolol in 109 samples by HPLC. Collected their NIR spectrograms data,calibration model of magnolol was established by the Partial least squares regression analysis. Result: The correlation coefficients (R2), the root-mean-square error of cross-validation and the root-mean-square error of calibration (RMSEC) of the calibration model for magnolol were 0.945 6,0.054 3,0.024 5; and the root-mean-square error of prediction (RMSEP) was 0.045 9, the average rate of recovery was 101.26%. Conclusion: The method is steady, accurate, and can be applied for the fast determination of magnolol within. Huoxiang Zhengqi capsules. |
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| Keywords: | near-infrared spectroscopy Huoxiang Zhengqi capsules magnolol HPLC |
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