| 不同纯化方法对金银花提取物中咖啡酰奎宁酸类成分含量的影响 |
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| 引用本文： | 邱新建,赵海鹏,刘向东,苏瑞强,李守信,赵志全.不同纯化方法对金银花提取物中咖啡酰奎宁酸类成分含量的影响[J].中国实验方剂学杂志,2013,19(8):83-86. |
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| 作者姓名： | 邱新建 赵海鹏 刘向东 苏瑞强 李守信 赵志全 |
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| 作者单位： | 鲁南制药集团股份有限公司,山东临沂 276006;中药制药共性技术国家重点实验室,山东临沂 276006;中药制药新技术山东省企业重点实验室,山东临沂 276006 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)项目(2012CB724001) |
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| 摘 要： | 目的:考察不同纯化方法对金银花提取物中咖啡酰奎宁酸类成分的影响.方法:应用醇沉法、石硫法、石硫醇法、大孔树脂吸附法及萃取法等对金银花进行提取纯化,并采用高效液相色谱法测定其中6种咖啡酰奎宁酸类成分的含量.结果:萃取法所得金银花提取物中咖啡酰奎宁酸类成分的含量最高,总咖啡酰奎宁酸含量达83.91％.结论:萃取法是制备金银花提取物的理想方法.
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| 关 键 词： | 金银花 咖啡酰奎宁酸 绿原酸 萃取法 高效液相色谱法 |
| 收稿时间： | 9/4/2012 12:00:00 AM |
Effects of Different Purification Methods on Content of Caffeoyl Quinic Acids from Flos Lonicerae Extractive |
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| QIU Xin-jian,ZHAO Hai-peng,LIU Xiang-dong,SU Rui-qiang,LI Shou-xin and ZHAO Zhi-quan.Effects of Different Purification Methods on Content of Caffeoyl Quinic Acids from Flos Lonicerae Extractive[J].China Journal of Experimental Traditional Medical Formulae,2013,19(8):83-86. |
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| Authors: | QIU Xin-jian ZHAO Hai-peng LIU Xiang-dong SU Rui-qiang LI Shou-xin and ZHAO Zhi-quan |
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| Institution: | Lunan Pharmaceutical Group Co. Ltd., Linyi 276006, China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi 276006, China;Shangdong Province Key Laboratory of Pharmaceutical New Technology of Chinese Traditional Medicine, Linyi 276006, China;Lunan Pharmaceutical Group Co. Ltd., Linyi 276006, China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi 276006, China;Shangdong Province Key Laboratory of Pharmaceutical New Technology of Chinese Traditional Medicine, Linyi 276006, China;Lunan Pharmaceutical Group Co. Ltd., Linyi 276006, China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi 276006, China;Shangdong Province Key Laboratory of Pharmaceutical New Technology of Chinese Traditional Medicine, Linyi 276006, China;Lunan Pharmaceutical Group Co. Ltd., Linyi 276006, China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi 276006, China;Shangdong Province Key Laboratory of Pharmaceutical New Technology of Chinese Traditional Medicine, Linyi 276006, China;Lunan Pharmaceutical Group Co. Ltd., Linyi 276006, China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi 276006, China;Shangdong Province Key Laboratory of Pharmaceutical New Technology of Chinese Traditional Medicine, Linyi 276006, China;Lunan Pharmaceutical Group Co. Ltd., Linyi 276006, China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi 276006, China;Shangdong Province Key Laboratory of Pharmaceutical New Technology of Chinese Traditional Medicine, Linyi 276006, China |
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| Abstract: | Objective: To study the effects of different purification ways on the extractive rate of caffeoyl quinic acids in Flos Lonicerae extractive. Method: Several purification processes were used respectively in the preparation of Flos Lonicerae extractive, such as alcohol precipitation method, lime-sulfur method, lime-sulfur ethanol method, macroporous resin method, and extraction method etc. The content of the six caffeoyl quinic acids was determined by HPLC. Result: The content of the caffeoyl quinic acids in Flos Lonicerae extractive by extraction method was higher than the other methods. Total content of caffeoyl quinic acids was up to 83.91%. Conclusion: The extraction method is the best in the preparation of Flos Lonicerae extractive. |
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| Keywords: | Flos Lonicerae caffeoyl quinic acids chlorogenic acid extraction method HPLC |
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