The importance of sentinel node biopsy in breast surgery |
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Authors: | A Haid P Schrenk S Roka Ch Tausch Barbara Pichler-Gebhard Margaretha Rudas G Zimmermann |
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Institution: | 1. From the Department of Surgery, Landeskrankenhaus Feldkirch, University of Vienna Austrian Sentinel Node Study Group of the ABCSG (Austrian Breast and Colorectal Cancer Study Group), Austria 2. Second Department of Surgery — Ludwig Boltzmann Institute for Surgical Laparoscopy, Allgemein ?ffentliches Krankenhaus Linz, University of Vienna Austrian Sentinel Node Study Group of the ABCSG (Austrian Breast and Colorectal Cancer Study Group), Austria 3. the Division of General Surgery, Department of Surgery, University of Vienna, University of Vienna Austrian Sentinel Node Study Group of the ABCSG (Austrian Breast and Colorectal Cancer Study Group), Austria 4. the Department of Surgery, Barmherzige Schwestern Hospital, Linz, University of Vienna Austrian Sentinel Node Study Group of the ABCSG (Austrian Breast and Colorectal Cancer Study Group), Austria 5. Department of Surgery, Landeskrankenhaus V?cklabruck, University of Vienna Austrian Sentinel Node Study Group of the ABCSG (Austrian Breast and Colorectal Cancer Study Group), Austria 6. Institute of Clinical Pathology, University of Vienna Austrian Sentinel Node Study Group of the ABCSG (Austrian Breast and Colorectal Cancer Study Group), Austria
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Abstract: | Summary
Background: In breast cancer patients the axillary nodes play an important role because of their predictive potential. But the merits
of routine diagnostic axillary dissection have increasingly been questioned in the past few years on account of the resultant
postoperative morbidity. Rediscovered and reinstated in the early 1980s, sentinel node biopsy (SNB) raised new hopes for differential
staging with minimal morbidity.
Methods: Based on a review of the available literature, the current role of sentinel node biopsy and its future perspectives are
discussed and critically evaluated.
Results: Sentinel node biopsy proved to be a practicable procedure for precise nodal staging in breast cancer patients associated
with low postoperative morbidity. Serial sections of the sentinel node and immunohistochemical assays provide detailed information
on lymphatic drainage and more precise staging information. As a by-product, sentinel node biopsy has re-opened the debate
about the importance of micrometastases. Clearly defined criteria for patient selection, interdisciplinary cooperation, careful
documentation and follow-up are the keys to its success.
Conclusions: Like breast-salvaging surgery, sentinel node biopsy appears to mark a major advance in the management of breast cancer patients.
More insights into the significance of micrometastases and the role of axillary dissection as well as into the usefulness
of SNB post-preoperative chemotherapy and in multicentric lesions can be expected.
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Keywords: | Breast cancer sentinel node biopsy lymphatic mapping micrometastases morbidity |
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