多层螺旋CT体素指数评估慢性阻塞性肺病空气潴留的研究

目的探讨肺部多层螺旋CT（MSCT）体素指数（VI）在慢性阻塞性肺病（COPD）空气潴留定性、定量评估中的价值。方法选取43例拟行胸部HRCT受检者行MSCT-DPVI，检查后1周内行肺功能测试。图像经后处理，分别设定呼吸双相的阈值，得到相应VI,各VI与PFT指标FEV1（％）、FEV1／FVC作统计学相关性分析，并通过ROC曲线找出界值。结果所有VI与FEV1／FVC和FEV1（％）均具显著相关性（P〈0．01）。与FEV1／FVC相关性最大的是呼气相VI-810（r=0．606，P〈0．01），其诊断界值是40％。与FEV1（％）相关性最大的是呼气相VI-790（r=0．661，P〈0．01）。结论MSCT呼气相VI-810和呼气相VI-790可分别作为评估COPD空气潴留的定性指标和半定量指标。

Study of voxel index from multislice CT in evaluating chronic obstructive pulmonary disease air-trapping

Objective To discuss the value of voxel index(VI) from multislice CT(MSCT) in qualitatively and quantitatively evaluating chronic obstructive pulmonary disease(COPD) air-trapping.Methods Forty-three subjects who were planned to take an HRCT scan of chest underwent MSCT dual phase volume imaging(MSCT-DPVI).Pulmonary function test was taken by all the subjects after MSCT-DPVI within the same week.By setting different CT values,different VI of inspiration phase and expiration phase were obtained from post processing.All the VI were compared statistically with PFT indexes FEV1(%) and FEV1/FVC,and the diagnose threshold value was found from ROC curve.Results All the VI were correlated with FEV1(%) and FEV1/FVC significantly(P<0.01).The VI most correlated with FEV1/FVC was expiratory VI-810(r=-0.606,P<0.01),and its threshold value was 40%.The VI most correlated with FEV1(%) was expiratory VI-790(r=-0.661,P<0.01).Conclusion The expiratory VI-810 and expiratory VI-790 of MSCT can be used as qualitative index and semi-quantitative index respectively to evaluate COPD air-trapping.