| 海洛因成瘾模型建立及中脑腹侧被盖区Bax的表达 |
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| 引用本文： | 俞发荣,连秀珍,谢明仁,张红梅,李立新,张琛,李世平.海洛因成瘾模型建立及中脑腹侧被盖区Bax的表达[J].实验动物与比较医学,2012(6):82-84. |
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| 作者姓名： | 俞发荣 连秀珍 谢明仁 张红梅 李立新 张琛 李世平 |
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| 作者单位： | 甘肃省证据科学技术研究与应用重点实验室, 兰州730070;甘肃省证据科学技术研究与应用重点实验室, 兰州730070;甘肃省证据科学技术研究与应用重点实验室, 兰州730070;甘肃省证据科学技术研究与应用重点实验室, 兰州730070;甘肃省证据科学技术研究与应用重点实验室, 兰州730070;甘肃省证据科学技术研究与应用重点实验室, 兰州730070;甘肃省证据科学技术研究与应用重点实验室, 兰州730070 |
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| 摘 要： | 目的探索海洛因对中脑腹侧被盖区细胞Bax表达的影响。方法肌肉注射海洛因,建立成瘾大鼠模型,用免疫组化方法检测中脑腹侧被盖区细胞Bax的表达。结果连续给大鼠注射海洛因7d后,大鼠出现明显的戒断症状；中脑腹侧被盖区细胞Bax表达阳性细胞比对照组明显增多,与对照组相比差异有显著性 (P<0.01)。结论海洛因具有诱导Bax基因表达、损伤脑组织细胞的作用。
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| 关 键 词： | 海洛因 Bax 中脑腹侧被盖区 大鼠 |
Effect of heroin on Bax expression in the brain ventral tegmental area and establishment of a rat model of heroin addiction |
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| YU Fa-rong,LIAN Xiu-zhen,XIE Ming-ren,ZHANG Hong-mei,LI Li-xin,ZHANG chen and LI Shi-ping.Effect of heroin on Bax expression in the brain ventral tegmental area and establishment of a rat model of heroin addiction[J].Laboratory Animal and Comparative Medicine,2012(6):82-84. |
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| Authors: | YU Fa-rong LIAN Xiu-zhen XIE Ming-ren ZHANG Hong-mei LI Li-xin ZHANG chen and LI Shi-ping |
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| Institution: | Key Laboratory of Evidence Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China;Key Laboratory of Evidence Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China;Key Laboratory of Evidence Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China;Key Laboratory of Evidence Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China;Key Laboratory of Evidence Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China;Key Laboratory of Evidence Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China;Key Laboratory of Evidence Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China |
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| Abstract: | |
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| Keywords: | Heroin Bax Midbrain ventral tegmental area (VTA) Addiction Rat |
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