IL-2与CD_4~+CD_(25)~+调节性T细胞的相关研究进展

白细胞介素2(IL-2)最早被称为T细胞生长因子,在体外能够有力地促进T细胞生长和扩增,而在体内IL-2的具体作用尚不清楚。CD4+CD2+5调节性T细胞是调节性T细胞的一个重要亚群,它能够以主动性的方式介导机体对自身抗原的免疫耐受以及抑制抗肿瘤免疫应答,但在体内其具体的免疫抑制机制目前还不清楚。有研究证实IL-2在CD4+CD2+5调节性T细胞胸腺发育和外周维持扩增中发挥重要作用,因此充分了解IL-2与CD4+CD2+5调节性T细胞的关系有助于更好的将其应用到临床的免疫治疗当中。

Progress of CD+4CD+25 T Regulatory Cells and Interlerkin-2

Historically,interleukin-2(IL-2) was known as a “T-cell growth factor”,which can strongly promote the growth and amplification of T cells in vitro although its mechanism of action in vivo is not very clear.CD+4CD+25 regulatory T cells is an important subpopulation,which can actively mediate immunological tolerance to autoantigen in organism and inhibit anti-tumor immunological response although its mechenism of immunosupression in vivo is not clear.Researches showed that IL-2 played an important role in the development of CD+4 CD+25 regulatory cells in thymus and maintainance and amplification in periphery.So sufficant recognition of their relationship will be helpful to apply it to immunotherapy in clinic.