米非司酮脂质体的制备及性质考察

目的研制米非司酮脂质体。方法采用薄膜分散法制备米非司酮脂质体，应用葡聚糖凝胶法测定包封率，并考察该脂质体的形态、粒径、稳定性和体外释放特性。结果所制备的米非司酮脂质体包封率达85．2％，平均粒径为112．7nm，4℃冷藏保存3个月稳定性良好，具有体外缓释作用。结论米非司酮脂质体制备工艺简单可行，脂质体制剂学性质稳定。

Preparation and Characterization of Mifepristone Liposome

Objective To prepare mifepristone liposomes. Methods The mifepristone liposomes were prepared by film hydration method and the encapsulation efficiency was determined by sephadex gel filtration. The morphology, particle size distribution, stability and in vitro release of liposomes were investigated, respectively. Results The encapsulation efficiency of the liposomes was 85.2%, and the average diameter of the liposomes was 112.7 nm. The liposomes remained quite stable in refrigerated preservation at 4 ℃ for 3 months. The profile of mifepristone release from liposomes was studied and the formulation was confirmed to have a sustained release effect. Conclusion The preparation technology of mifepristone liposomes is easy and practicable. The pharmaceutical characterization of the liposomes is stable.