| 人参皂苷Rg3联合紫杉醇抗胃癌转移的作用及机制研究 |
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| 引用本文： | 袁国荣,叶再元.人参皂苷Rg3联合紫杉醇抗胃癌转移的作用及机制研究[J].中华中医药学刊,2011(3):625-628. |
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| 作者姓名： | 袁国荣 叶再元 |
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| 作者单位： | 浙江省人民医院; |
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| 摘 要： | 目的:探讨人参皂苷Rg3联合紫杉醇协同抗胃癌转移的作用及机制。方法:将人胃癌BGC—823细胞裸鼠移植瘤动物模型,随机分为四组(每组10只):人参皂苷Rg3组GS-Rg3:10mg/(kg.d)灌胃]),紫杉醇组(10 mg/kg腹腔内注入,每周二次),联合组(人参皂苷Rg3+紫杉醇,用法同上),对照组(生理盐水组)。连续用药3周。用药结束后脱颈处死裸鼠,统计各组转移率,免疫组化检测微血管密度(MVD),RT-PCR测定血管生成因子β3-整合素的mRNA水平。结果:联合组肿瘤转移率低于紫杉醇组和人参皂苷Rg3组(P<0.05,P<0.01),联合组肿瘤微血管密度(MVD)最低,与人参皂苷Rg3组和紫杉醇组比较有显著差异(P<0.05和P<0.01),联合组β3-整合素最低,与紫杉醇组、人参皂苷Rg3组比较均有显著差异(P<0.05,P<0.01).结论:人参皂苷Rg3联合紫杉醇具有协同抗胃癌转移作用,可能通过协同抑制肿瘤新生血管形成有关。
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| 关 键 词： | 胃癌 转移 人参皂苷Rg3 紫杉醇 β3-整合素 |
Experiment Study of Gisenoside Rg3 and Paclitaxel on inhibiting Gastric Cancer Cells' Metastasis and Its Mechanism |
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| YUAN Guo-rong,YE Zai-yuan.Experiment Study of Gisenoside Rg3 and Paclitaxel on inhibiting Gastric Cancer Cells' Metastasis and Its Mechanism[J].Chinese Archives of Traditional Chinese Medicine,2011(3):625-628. |
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| Authors: | YUAN Guo-rong YE Zai-yuan |
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| Institution: | YUAN Guo-rong,YE Zai-yuan(Zhejiang Provincal People' Hospital,Hangzhou 310014,Zhejiang,China) |
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| Abstract: | Objective:To explore inhibiting Gastric cancer Cells' Metastasis and Its Mechanism of Gisenoside Rg3 and Paclitaxel.Methods: Transplantation tumor models of gastric cancer cells BGC-823 in SCID mice were randomly divided into four groups(10 mice per group): Ginsenoside Rg3 group(GS-Rg3: 10mg/Kg/d intragastric administration,for three weeks),Paclitaxel group(Paclitaxel at 10mg/Kg was injected into abdominal cavity two times per week,for three weeks),the combined group(GS-Rg3+ Paclitaxel,using the same method... |
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