| 温阳涩肠方对番泻叶致小鼠腹泻作用的实验研究 |
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| 引用本文： | 李雪萍,石永生,张永东,梁涛,王永军,刘英,王玉梅.温阳涩肠方对番泻叶致小鼠腹泻作用的实验研究[J].中华中医药学刊,2011(1):84-85. |
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| 作者姓名： | 李雪萍 石永生 张永东 梁涛 王永军 刘英 王玉梅 |
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| 作者单位： | 甘肃省医学科学研究院药理毒理室;甘肃省妇幼保健院儿科; |
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| 基金项目： | 甘肃省科技厅2009年科技支撑计划项目(097NKCA107) |
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| 摘 要： | 目的:观察温阳涩肠法对番泻叶致小鼠腹泻指数及正常小鼠小肠推进运动的影响。方法:采用药物性腹泻小鼠模型和碳末推进法。结果:小鼠灌服温阳涩肠药大剂量(83.75g/kg)、中剂量(41.87g/kg),腹泻指数分别为0.59、0.40,与模型对照组腹泻指数1.01比较,差异均有显著性(P<0.05);温阳涩肠药大剂量、中剂量及复方地芬诺酯均能明显抑制正常小鼠炭末推进率,其推进率分别为56.06%、61.91%和56.14%,与空白对照组推进率65.92%相比,差异有显著性(P<0.05);与阳性对照组比较,大剂量的抑制效应与复方地芬诺酯(6.2mg/kg)相当(P>0.05)。结论:温阳涩肠法具有一定的止泻作用及抑制肠蠕动作用。
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| 关 键 词： | 温阳涩肠 番泻叶 止泻 腹泻指数 小肠推进 |
Experimental Research of Wenyangsechang Decoction on Diarrhea Induced by Sennae Folium in Mice |
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| LI Xue-ping,SHI Yong-sheng,ZHANG Yong-dong,LIANG Tao,WANG Yong-jun,LIU Ying,WANG Yu-mei.Experimental Research of Wenyangsechang Decoction on Diarrhea Induced by Sennae Folium in Mice[J].Chinese Archives of Traditional Chinese Medicine,2011(1):84-85. |
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| Authors: | LI Xue-ping SHI Yong-sheng ZHANG Yong-dong LIANG Tao WANG Yong-jun LIU Ying WANG Yu-mei |
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| Institution: | LI Xue-ping1,SHI Yong-sheng2,ZHANG Yong-dong1,LIANG Tao1,WANG Yong-jun2,LIU Ying1,WANG Yu-mei1(1.Pharmacology and Toxicology Center,Gansu Province Medical Science Institute,Lanzhou 730050,Gansu,China,2.Pediatrics of Gansu Maternal and Child Health Hospital,China) |
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| Abstract: | Objective: To observe the effect of Wenyangsechang(WYSC) decoction on diarrhea induced by sennae folium and intestinal propulsion in mice.Methods:The effects of WYSC decoction on diarrhea model mice and the charcoal-pushing of the intestines in normal mice were observed.Results: The diarrhea indexes of WYSC decoction with high and middle dose were significantly lower than model group(P<0.05).In the charcoal pushing of the intestines test,the inhibiton ratios of WYSC decoction were significantly higher than ... |
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| Keywords: | Wenyangsechang sennae folium antidiarrheal activity diarrhea index intestinal propulsion |
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