| 益气补肾方对SGC-7901细胞MMP-2和TIMP-2基因表达的影响 |
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| 引用本文： | 刘云霞,姚立,姚勇伟,杨洁文,蒋沈君. 益气补肾方对SGC-7901细胞MMP-2和TIMP-2基因表达的影响[J]. 中华中医药学刊, 2011, 0(7): 1639-1642 |
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| 作者姓名： | 刘云霞 姚立 姚勇伟 杨洁文 蒋沈君 |
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| 作者单位： | 杭州市第三人民医院;浙江中医药大学; |
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| 基金项目： | 杭州市卫生科技计划项目(2009A014) |
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| 摘 要： | 目的:探究益气补肾方抗胃癌转移作用的可能机理。方法:采用RT-PCR检测法测定益气补肾方水煎液对SGC-7901细胞基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶抑制酶-2(TIMP-2)基因表达水平的变化。结果:益气补肾方能下调MMP-2 mRNA的表达。结论:益气补肾方抗胃癌转移作用的机制可能与下调MMP-2 mRNA表达有关。
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| 关 键 词： | 益气补肾方 胃癌 MMP-2 TIMP-2 |
Effect of YiQiBuShen Formula in Expression of SGC-7901 cells MMP-2 and TIMP-2 |
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| LIU Yun-xia,YAO Li,YAO Yong-wei,JIANG Chen-jun,YANG Jie-wen. Effect of YiQiBuShen Formula in Expression of SGC-7901 cells MMP-2 and TIMP-2[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(7): 1639-1642 |
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| Authors: | LIU Yun-xia YAO Li YAO Yong-wei JIANG Chen-jun YANG Jie-wen |
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| Affiliation: | LIU Yun-xia1,YAO Li2,YAO Yong-wei1,JIANG Chen-jun1,YANG Jie-wen1(1.The Third People's Hospital of Hangzhou City,Hangzhou 310009,Zhejiang,China 2.Zhejiang University of Chinese Medicine,Hangzhou 310053,China) |
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| Abstract: | Objective:Explore the possible mechanism of gastric cancer metastasis of YiQiBuShen Formula.Methods:The effect of YiQiBuShen Formula on the gene expression of Matrix metalloproteinase-2(MMP-2) and tissue inhibitor of Tissueinhibitors of metalloproteinase-2(TIMP-2) of SGC-7901 cells was tested by RT-PCR assay.Results:YiQiBuShen Formula could down-regulate the expression of MMP-2 mRNA.Conclusion:The inhibition effect of YiQiBuShen Formula may be related to down-regulating the expression of MMP-2 mRNA. |
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| Keywords: | YiQiBuShen Formula Gastric cancer MMP-2 TIMP-2 |
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