| 复方丹参饮对胰岛素抵抗大鼠血管内皮细胞ICAM-1、VCAM-1表达的研究 |
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| 引用本文： | 吴宝庆,王蕊,徐京育,李寒梅. 复方丹参饮对胰岛素抵抗大鼠血管内皮细胞ICAM-1、VCAM-1表达的研究[J]. 中华中医药学刊, 2011, 0(7): 1617-1618 |
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| 作者姓名： | 吴宝庆 王蕊 徐京育 李寒梅 |
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| 作者单位： | 黑龙江中医药大学;黑龙江中医药大学附属第一医院; |
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| 基金项目： | 黑龙江省教委资助项目(11531356) |
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| 摘 要： | 目的:探讨复方丹参饮对胰岛素抵抗(IR)大鼠血清中细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)的表达。方法:将60只Wistar雄性大鼠适应性的喂养1周,随机分为生理盐水组、胰岛素抵抗组、复方丹参饮预防组(中药预防组)复方丹参饮治疗组(中药治疗组)、罗格列酮组(西药对照组),每组分为12只。采用高脂高糖高胆固醇饮食喂养,建立大鼠IR模型。喂养16周以后采用酶联免疫法检测各组Wistar大鼠血清中ICAM-1、VCAM-1的含量。结果:与生理盐水组比较,除复方丹参饮预防组差异无统计学意义外(P>0.05),其余各组大鼠血清中ICAM-1、VCAM-1的含量均升高(P<0.05),有统计学意义;与胰岛素抵抗组相比较,西药对照组、中药治疗组与中药预防组均能减少大鼠血清中ICAM-1、VCAM-1的含量(P<0.05)。结论:认为复方丹参饮具有抑制大鼠血清血管内皮细胞ICAM-1、VCAM-1的过度表达作用,对胰岛素抵抗大鼠的血管内皮细胞具有保护功效。
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| 关 键 词： | 胰岛素抵抗(IR) 血管内皮细胞 细胞间黏附分子-1(ICAM-1) 血管细胞黏附分子-1(VCAM-1) |
Study the Expressions of Compound Danshen Decoction on ICAM-1 and VCAM-1 in Rats with Insulin Resistance |
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| WU Bao-qing,WANG Rui,XU Jing-yu,LI Han-mei. Study the Expressions of Compound Danshen Decoction on ICAM-1 and VCAM-1 in Rats with Insulin Resistance[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(7): 1617-1618 |
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| Authors: | WU Bao-qing WANG Rui XU Jing-yu LI Han-mei |
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| Affiliation: | WU Bao-qing1,WANG Rui1,XU Jing-yu2,LI Han-mei2(1.Heilongjiang Univesity of TCM,Harbin 150040,Heilongjiang,China,2.First Affiliated Hospital of Heilongjiang Univesity of TCM,China) |
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| Abstract: | Objective:To study the expressions of Compound Danshen Decoction on serum intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) in rats with insulin resistance(IR).Methods:Sixty Wistar male rats,which were feeding adaptively for a week,were randomly divided into 5 groups:the Saline group,IR group,the Compound Danshen Decoction prevention group(the Chinese Medicine prevention group),the Compound Danshen Decoction treatment group(the Chinese Medicine treatment group) and the ... |
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| Keywords: | insulin resistance(IR) vascular endothelial cells intercellular adhesion molecule-1(ICAM-1) vascular cell adhesion molecule-1(VCAM-1) |
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