| 补肾冲剂联合干扰素治疗慢性乙型肝炎及其对树突状细胞的影响 |
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| 引用本文： | 孙学华,郑亚江,李曼,朱晓骏,商斌仪,杨婉凤,卓蕴慧,高月求.补肾冲剂联合干扰素治疗慢性乙型肝炎及其对树突状细胞的影响[J].中华中医药学刊,2011(6):1270-1273. |
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| 作者姓名： | 孙学华 郑亚江 李曼 朱晓骏 商斌仪 杨婉凤 卓蕴慧 高月求 |
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| 作者单位： | 上海中医药大学附属曙光医院肝病科国家中管局细胞免疫实验室;上海市中医院; |
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| 基金项目： | 国家自然科学基金资助项目(81072792)上海市教育委员会E研究院建设计划项目(03008); 上海市科委引导项目(074119608); 上海市浦东新区创新项目; 上海中医药大学优秀团队培养计划; 上海高校创新团队建设项目; 上海市教育委员会重点学科(第5期)建设资助项目(J50307); 上海市教委项目(05cz18); 上海市自然基金(10ZR1430900); 上海市科委优秀学科带头人计划(10XD1404100) |
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| 摘 要： | 目的:观察干扰素联合补肾冲剂治疗慢性乙型肝炎(chron ic hepatitis B,CHB)的疗效,探讨该药物对CHB患者树突状细胞(dentritic cells,DCs)的影响。方法:收集CHB患者60例,随机分为治疗组及对照组,治疗组给予补肾冲剂联合干扰素治疗,对照组单用干扰素治疗,疗程均为6个月。分离扩增外周血单个核细胞中DC,流式细胞法检测DC表面CD86、CD80、CD40、CD14、CD11c、HLA-DR的表达。检测同种异体T淋巴细胞混合培养后的刺激指数及培养上清液中IFN-γ、IL-10表达。结果:治疗后治疗组ALT、AST改善较对照组明显,P<0.05;治疗后治疗组HBVDNA对数均值明显低于对照组,具有显著差异(P<0.05)。治疗后治疗组淋巴细胞混合实验中IFN-γ明显高于对照组(P<0.05)。结论:中药补肾冲剂与干扰素联合治疗CHB在改善肝功能、降低HBVDNA数量方面疗效更,且对IFN-γ有明显的升高作用,提示其疗效机理可能在于提高患者的细胞免疫能力。
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| 关 键 词： | 补肾冲剂 干扰素 慢性乙型肝炎 肝功能 HBVDNA 树突状细胞 |
Clinical Effect and Affect on Dentritic Cells Function of Bushen Recipe Combined with Interferon on CHB Patients |
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| SUN Xue-hua,ZHENG Ya-jiang,LI Man,ZHU Xiao-jun,SHANG Bin-yi,YANG Wan-feng,ZHUO Yun-hui,GAO Yue-qiu.Clinical Effect and Affect on Dentritic Cells Function of Bushen Recipe Combined with Interferon on CHB Patients[J].Chinese Archives of Traditional Chinese Medicine,2011(6):1270-1273. |
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| Authors: | SUN Xue-hua ZHENG Ya-jiang LI Man ZHU Xiao-jun SHANG Bin-yi YANG Wan-feng ZHUO Yun-hui GAO Yue-qiu |
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| Institution: | SUN Xue-hua1,ZHENG Ya-jiang2,LI Man1,ZHU Xiao-jun1,SHANG Bin-yi1,YANG Wan-feng1,ZHUO Yun-hui1,GAO Yue-qiu1(1.Shuguang Hospital Affliated to Shanghai University of TCM CellularImmunity Laboratory of State Administration of TCM of China,Shanghai 201210,China,2.Shanghai hospital of TCM,Shanghai 200090,China) |
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| Abstract: | Objective:To observe the effect of Bushen recipe combined with interferon on chronic hepatitis B(CHB) and study the effect on dentritic cells(DCs) function in CHB patients.Methods:A total of 60 CHB patients were enrolled and randomly divided into treatment and control groups,patients in the treatment group were given Bushen recipe combined with interferon therapy,while patients in the control group were only given interferon therapy.Both the therapies lasted for 6 months.DCs were isolated from peripheral bl... |
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| Keywords: | Bushen recipe interferon chronic hepatitis B liver function HBV DNA dentritic cells |
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