| 肝复健冲剂对大鼠肝纤维化形成的影响 |
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| 引用本文： | 梁璇,孙德国. 肝复健冲剂对大鼠肝纤维化形成的影响[J]. 中华中医药学刊, 2011, 0(6): 1381-1382 |
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| 作者姓名： | 梁璇 孙德国 |
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| 作者单位： | 辽宁中医药大学附属医院; |
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| 摘 要： | 目的:观测中药肝复健冲剂对二乙基亚硝胺(DEN)诱导大鼠肝纤维化形成的影响.方法:建立DEN诱导大鼠肝硬化模型,同时给予肝复健冲剂进行干预,应用天狼红苦味酸特染法、免疫组化染色法及计算机图像分析技术检测中药对DEN致大鼠肝纤维化过程胶原沉淀及肝细胞增殖特性的影响.结果:随着模型大鼠肝纤维化程度加重,肝内胶原沉积量相应逐渐增加.中药组大鼠肝脏炎性损害及肝纤维化程度均较同期模型组大鼠轻,胶原沉积量及细胞增殖核抗原(PCNA)阳性着色肝细胞数明显减少,两组间差异有统计学意义,[胶原沉积量:4周(15.20±2.20)vs(7.19±0.96);12周(27.1±4.5)vs(16.0±1.6)。阳性表达PCNA肝细胞数:12周(21.1±0.31)vs(6.4±0.1);16周(31.1±7.0)vs(10.1±0.7)]。结论:中药肝复健冲剂可通过减少肝内胶原沉积及可能恶性增殖的肝细胞,抑制和延缓实验性动物肝纤维化的形成,并一定程度上预防肝硬化向肝癌的转变.
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| 关 键 词： | 肝复健冲剂 肝硬化 胶原 |
Influence of Ganfujian Granule Formula on Process of Liver Fibrosis in Rat |
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| LIANG Xuan,SUN De-guo. Influence of Ganfujian Granule Formula on Process of Liver Fibrosis in Rat[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(6): 1381-1382 |
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| Authors: | LIANG Xuan SUN De-guo |
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| Affiliation: | LIANG Xuan,SUN De-guo(Affiliated Hospital of Liaoning University of TCM,Shenyang 110032,Liaoning,China) |
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| Abstract: | Objective:To investigate the effect of ganfujian granule on collagen sediment in rat hepatic fibrosis induced by diethylnitrosamine(DEN).Methods:DEN induced live fibrosis model was established and ganfujian(GFJ) granule was administrated as intervention measure.Influence(EFJ group) of ganfujian granule on collagen sediment and hepatocyte proliferation were examined by Picric acidSirus red staining and immunohistochemical staing methods,and analyzed by computer image analysis technique.Results:Collagen sedim... |
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| Keywords: | ganfujian granule traditional medicine liver cirrhosis collagen |
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