| 局部和远道电针对根性痛大鼠脊髓背角及背根神经节NOS的表达影响 |
| |
| 引用本文： | 程博,屠文展,楼新法,庞玲霞,蒋松鹤.局部和远道电针对根性痛大鼠脊髓背角及背根神经节NOS的表达影响[J].中华中医药学刊,2011(2):317-320. |
| |
| 作者姓名： | 程博 屠文展 楼新法 庞玲霞 蒋松鹤 |
| |
| 作者单位： | 温州医学院附属第二医院;温州医学院基础学院; |
| |
| 基金项目： | 浙江省教育厅资助项目(20051157) |
| |
| 摘 要： | 目的:通过同节段局部和远道电针干预治疗慢性根性痛模型大鼠,观察其对脊髓背角及背根神经节中一氧化氮合酶(NOS)活性变化的影响。方法:采用慢性根性痛大鼠模型,将30只雄性Wistar大鼠随机分为正常对照组(A组)、模型组(B组)、局部电针组(C组,取双侧L4"夹脊"穴)、远端电针组(D组,取双侧"阳陵泉")。通过NADPH-d组织化学染色,观察电针后脊髓背角及背根神经节NOS表达的变化。结果:患侧脊髓背角及DRG中NADPH-d阳性反应结果一致:B、C、D组较A组均增加明显(P<0.01),其中,B组增加尤其明显,较C、D组差异有显著统计学意义(P<0.01);C组阳性表达较D组降低,差异有统计学意义(P<0.05)。结论:电针的镇痛作用可能部分是通过抑制NOS的活性实现的。同节段局部电针组抑制NOS活性的作用较强。
|
| 关 键 词： | 电针 神经病理性痛 脊髓背角 背根神经节 NOS |
Effects of Electro-Acupuncture on Local and Distant Coordinate Acupoints on the Expression of NOS in the Same Segments of Spinal Cord Dorsal Horn and DRGs in the Rats with Chronic Radicular Pain |
| |
| CHENG Bo,TU Wen-zhan,LOU Xin-fa,PANG Lin-xia,JIANG Song-he.Effects of Electro-Acupuncture on Local and Distant Coordinate Acupoints on the Expression of NOS in the Same Segments of Spinal Cord Dorsal Horn and DRGs in the Rats with Chronic Radicular Pain[J].Chinese Archives of Traditional Chinese Medicine,2011(2):317-320. |
| |
| Authors: | CHENG Bo TU Wen-zhan LOU Xin-fa PANG Lin-xia JIANG Song-he |
| |
| Institution: | CHENG Bo1,TU Wen-zhan1,LOU Xin-fa2,PANG Lin-xia2,JIANG Song-he1(1.The 2nd Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027,Zhejiang,China,2.Wenzhou Medical College,China) |
| |
| Abstract: | Objective:To observe the expression of NOS in the same segments of spinal cord dorsal horn and DRGs in the rats with chronic radicular pain,and to investigate whether there was different affection and different neurochemical mechanism of electro-acupuncture(EA)on local and distant coordinate acupoints to Neuropathic pain rats.Methods:After the model of the rats with sciatic nerve Clamping being made successfully,thirty male Wistar rats were divided into four groups randomly,including normal control group(Gr... |
| |
| Keywords: | electro-acupuncture neuropathic pain Spinal cord dorsal horn DRG nitricoxide synthase |
| 本文献已被 CNKI 等数据库收录！ |
|
