| 复方土茯苓颗粒提取、醇沉工艺研究 |
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| 引用本文： | 刘志刚,邓伟杰,郑鹏成,孙维峰,吴新荣. 复方土茯苓颗粒提取、醇沉工艺研究[J]. 中华中医药学刊, 2011, 0(7): 1594-1595 |
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| 作者姓名： | 刘志刚 邓伟杰 郑鹏成 孙维峰 吴新荣 |
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| 作者单位： | 广州军区广州总医院药剂科;广州中医药大学; |
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| 基金项目： | 广东省科技计划项目(2009B030801277); 广东省中医药局建设中医药强省立项课题(2009287) |
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| 摘 要： | 目的:建立复方土茯苓颗粒的提取、纯化工艺。方法:采用正交试验优化复方土茯苓颗粒提取、醇沉工艺;采用HPLC法测定提取物中牛膝含有的蜕皮甾酮。结果:确定提取工艺为第1次用8倍量水煎煮1h,第2次用7倍量水煎煮1h;醇沉工艺为将药液浓缩至0.5g/mL(相当于药材),边搅拌边加适量乙醇至浓度为60%,静置12h,分离上清液。结论:验证试验表明,该提取、醇沉工艺客观可行、稳定合理,可为工业化生产提供理论依据。
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| 关 键 词： | 复方土茯苓颗粒 正交试验 蜕皮甾酮 HPLC |
Study on Extracting and Alcohol Precipitating Craft of Compound Tufuling Granules |
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| LIU Zhi-gang,,DENG Wei-jie,ZHENG Peng-cheng,SUN Wei-feng,WU Xin-rong. Study on Extracting and Alcohol Precipitating Craft of Compound Tufuling Granules[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(7): 1594-1595 |
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| Authors: | LIU Zhi-gang DENG Wei-jie ZHENG Peng-cheng SUN Wei-feng WU Xin-rong |
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| Affiliation: | LIU Zhi-gang1,2,DENG Wei-jie1,ZHENG Peng-cheng2,SUN Wei-feng1,WU Xin-rong1 (1.General Hospital of Guangzhou Military Command of PLA,Guangzhou 510010,Guangdong,China,2.Guangzhou University of TCM,Guangzhou 510405,China) |
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| Abstract: | Objective:To optimize the extracting and alcohol precipitating craft of compound Tufuling granules by Orthogonal experiment.Methods:Orthogonal experiment was applied to optimize the influence factors of extracting and alcohol precipitating;ecdysterone in Radix Achyranthis Bidentatae of compound Tufuling granules concrete was determined by HPLC.Results:The best extraction craft is that the herbs should be extracted by 8 times(V/V) water for 1h,then be extracted by 7 times water for 1h;The best alcohol precip... |
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| Keywords: | compound Tufuling granules Orthogonal Experiment Ecdysterone HPLC |
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