| 复方丹参片对急性脑缺血大鼠血管新生因子影响的研究 |
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| 引用本文： | 余小平,张超群,覃仁安,周德生,胡华,高晓峰.复方丹参片对急性脑缺血大鼠血管新生因子影响的研究[J].中华中医药学刊,2011(5):1145-1148. |
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| 作者姓名： | 余小平 张超群 覃仁安 周德生 胡华 高晓峰 |
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| 作者单位： | 湖南中医药大学第一附属医院;广州白云山和记黄埔中药有限公司现代中药研究院; |
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| 摘 要： | 目的:探讨复方丹参片对急性脑缺血大鼠血管新生因子影响。方法:采用栓线法制备大鼠脑缺血模型。实验分为正常组、假手术组、模型组术、血塞通片组、复方丹参片组五组,术后后正常组、假手术组、模型组术蒸馏水灌胃,血塞通片组予于血塞通片灌胃,复方丹参片组予于复方丹参片灌胃。分别在24h,3天,7天等时间点对以上5组进行神经功能缺损评分,然后断头取脑,TTC染色观察脑梗死面积,免疫组织化学方法观察梗死周围区脑组织VEGF和bFGF蛋白的表达。结果:复方丹参片可明显改善急性脑缺血大鼠的神经功能,缩小梗死面积,显著增加大鼠脑内VEGF和bFGF蛋白的表达,促进急性脑缺血大鼠脑缺血组织侧枝循环的建立。结论:复方丹参片增强急性脑缺血大鼠梗死灶周围血管生长因子的表达,促进了梗死灶周围的血管新生。
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| 关 键 词： | 复方丹参片 急性脑缺血 血管生长因子 |
Research on Efect of Endothelial Growth Factor of Compound Salvia Tablet on Rats with Cerebral Ischemia |
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| YU Xiao-ping ,ZHANG Chao-qun,QIN Ren-an,ZHOU De-sheng,HU Hua,GAO Xiao-feng.Research on Efect of Endothelial Growth Factor of Compound Salvia Tablet on Rats with Cerebral Ischemia[J].Chinese Archives of Traditional Chinese Medicine,2011(5):1145-1148. |
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| Authors: | YU Xiao-ping ZHANG Chao-qun QIN Ren-an ZHOU De-sheng HU Hua GAO Xiao-feng |
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| Institution: | YU Xiao-ping 1,ZHANG Chao-qun1,QIN Ren-an2,ZHOU De-sheng1,HU Hua1,GAO Xiao-feng1(1.First Affiliated Hospital of Hunan University of Chinese Medicine,Changshua 410007,Hunan,China,2.Guangzhou Baiyun Mount Hutchhison Whampoa Chinese Medicine Ltd.Modern Chinese Medicine Research Institue,Guangzhou 510515,Guangdong,China) |
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| Abstract: | Objective:To explore the Efect of Endothelial Growth Factor of Salvia on rats with cerebral ischemia.Methods:Cerebral ischemia model after middle cerebral artery occlusion(MCAO)in rats was induced by the method of nylon monofilament via external carotid artery.artery.Rats were divided randomly into normol group,ischemia model group,sham operation group,ischemia model with Xuesaitong tablet treatmen group,ischemia model with Compound salvia tablet treatmen group.Normol group,ischemia model group,sham operati... |
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| Keywords: | Compound salvia tablet Vascular endothelial growth factor Rats with cerebral ischemia |
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