| 人参皂苷Rg3联合紫杉醇协同诱导胃癌细胞凋亡的研究 |
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| 引用本文： | 袁国荣,叶再元.人参皂苷Rg3联合紫杉醇协同诱导胃癌细胞凋亡的研究[J].中华中医药学刊,2011(6):1383-1386. |
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| 作者姓名： | 袁国荣 叶再元 |
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| 作者单位： | 浙江省人民医院; |
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| 摘 要： | 目的:探讨人参皂苷Rg3联合紫杉醇是否具有协同诱导胃癌细胞凋亡的作用。方法:将人胃癌BGC—823细胞裸鼠移植瘤动物模型,随机分为4组(每组10只):人参皂苷Rg3组(GS-Rg3:10mg.kg-1.d-1灌胃),紫杉醇组(紫杉醇10 mg/kg腹腔内注入,每周2次),联合组(人参皂苷Rg3+紫杉醇,用法同上),对照组(生理盐水组)。连续用药三周。用药结束后脱颈处死裸鼠,统计各组抑瘤率;流式细胞仪检测移植瘤细胞凋亡率,RT-PCR测定凋亡关键因子Caspase-3水平,电镜观察肿瘤细胞凋亡状态。结果:联合组(人参皂苷Rg3+紫杉醇)抑瘤率明显大于人参皂苷Rg3组和紫杉醇组(P<0.01);联合组肿瘤细胞凋亡率明显大于紫杉醇及人参皂苷Rg3组(P<0.01),联合组Caspase-3水平最高,与紫杉醇组、人参皂苷Rg3组比较有显著差异(P<0.05和P<0.01)。结论:人参皂苷Rg3联合紫杉醇能协同诱导胃癌细胞凋亡,抑制肿瘤的生长。
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| 关 键 词： | 胃癌 人参皂苷Rg3 紫杉醇 细胞凋亡 |
Experiment Study of Gisenoside Rg3 and Paclitaxel on Inducing Gastric Cancer Cells' Apoptosis |
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| YUAN Guo-rong,YE Zai-yuan.Experiment Study of Gisenoside Rg3 and Paclitaxel on Inducing Gastric Cancer Cells' Apoptosis[J].Chinese Archives of Traditional Chinese Medicine,2011(6):1383-1386. |
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| Authors: | YUAN Guo-rong YE Zai-yuan |
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| Institution: | YUAN Guo-rong,YE Zai-yuan(Zhe Jiang Provincal People' Hospital,Hangzhou 310006,Zhejiang,China) |
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| Abstract: | Objective:To study whether Ginsenoside Rg3 combined with Paclitaxel could induce gastric cancer cells' apoptosis.Methods: Transplantation tumor models of gastric cancer cells BGC-823 in SCID mice were randomly divided into four groups(10 mice per group): Ginsenoside Rg3 group(GS-Rg3: 10mg/Kg/d intragastric administration,for three weeks),Paclitaxel group(Paclitaxel at 10mg/Kg was injected into abdominal cavity two times per week,for three weeks),the combined group(GS-Rg3+ Paclitaxel,using the same method ab... |
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| Keywords: | gastric tumor GS-Rg3 Paclitaxel cell apoptosis |
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